A Polypyrrole/Nanoclay Hybrid Film for Ultra-Sensitive Cardiac Troponin T Electrochemical Immunosensor

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Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.creatorLandim, Vicente P. A.-
Autor(es): dc.creatorFoguel, Marcos V.-
Autor(es): dc.creatorPrado, Cecília M.-
Autor(es): dc.creatorSotomayor, Maria P. T.-
Autor(es): dc.creatorVieira, Iolanda C.-
Autor(es): dc.creatorSilva, Bárbara V. M.-
Autor(es): dc.creatorDutra, Rosa F.-
Data de aceite: dc.date.accessioned2025-08-21T22:07:05Z-
Data de disponibilização: dc.date.available2025-08-21T22:07:05Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/bios12070545-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240700-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240700-
Descrição: dc.descriptionAn electrochemical immunosensor based on a nanohybrid film of carboxylated polypyrrole and amine nanoclay was developed for label-free detection of the human cardiac troponin T (cTnT). The nanohybrid film was formed in situ on the surface of the glassy carbon electrode, followed by the covalent immobilization of anti-troponin T antibodies by glutaraldehyde. Morphological and chemical characterizations of the nanohybrid film were performed by scanning electron microscopy and Fourier-transform infrared spectroscopy. Under the optimized conditions, a calibration curve for cTnT in spiked serum was obtained by square wave voltammetry, and a low limit of detection and quantification was achieved (0.35 and 1.05 pg mL−1, respectively). This was the first time that this type of nanohybrid film was used in the development of an immunosensor for cTnT that proved to be a simple and efficient strategy for the manufacture of a label-free electrochemical device that could be applied in the diagnosis of acute myocardial infarction.-
Descrição: dc.descriptionBiomedical Engineering Laboratory Department of Biomedical Engineering Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235-
Descrição: dc.descriptionInstitute of Chemistry State University of São Paulo (UNESP-
Descrição: dc.descriptionLaboratory of Biosensors Department of Chemistry Federal University of Santa Catarina (UFSC-
Descrição: dc.descriptionInstitute of Chemistry State University of São Paulo (UNESP-
Idioma: dc.languageen-
Relação: dc.relationBiosensors-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcardiac troponin T-
Palavras-chave: dc.subjectimmunosensor-
Palavras-chave: dc.subjectnanoclay-
Palavras-chave: dc.subjectpolypyrrole-
Título: dc.titleA Polypyrrole/Nanoclay Hybrid Film for Ultra-Sensitive Cardiac Troponin T Electrochemical Immunosensor-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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