Charge and rigidity effects on the encapsulation of quercetin by multilamellar vesicles

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Triângulo Mineiro-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCustódio, Luciana-
Autor(es): dc.creatorMendes, Leandro Antunes-
Autor(es): dc.creatorAlvares, Dayane S-
Autor(es): dc.creatorMoreto, Jéferson Aparecido-
Autor(es): dc.creatorSlade, Natália Bueno Leite-
Data de aceite: dc.date.accessioned2025-08-21T17:40:52Z-
Data de disponibilização: dc.date.available2025-08-21T17:40:52Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12034-022-02734-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240610-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240610-
Descrição: dc.descriptionAlthough quercetin has a wide range of applications due to its biological properties, its activity may be affected due to its low solubility and its potential for degradation in a physiological environment. The nanoparticulate and microparticulate systems appear as a powerful strategy to enhance its biological activity as well as to contribute to the viability of this compound for pharmacological purposes. Here, we present an innovative and applied research to study the effect of different lipid compositions on the encapsulation of quercetin by using multilamellar vesicles (MLVs). For this purpose, the effects of charge and rigidity in the formulation’s average size, size distribution, charge properties, encapsulation and release efficiencies of this polyphenol were explored. Our results demonstrated that the rigidity imposed by cholesterol increased both the homogeneity of the size distribution and the encapsulation efficiency enabling a significant rate of quercetin release at the system with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/cholesterol (80:20). The charge modulated both the average size and size distribution as well as resulted in high encapsulation and release efficiencies in the formulation composed by (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (80:20). To the best of our knowledge, this is the first study concerning charge and rigidity effects on the encapsulation of quercetin in MLVs. Furthermore, the findings presented in this work is a starting point on the use of lipid composition as a modulating agent of important parameters in the development of nano and micro systems for controlled release. Graphical abstract: [Figure not available: see fulltext.]-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionDepartment of Physics Federal University of Triângulo Mineiro-
Descrição: dc.descriptionDepartment of Physics São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Physics São Paulo State University, SP-
Descrição: dc.descriptionCNPq: 303659/2019-0-
Descrição: dc.descriptionFAPEMIG: APQ-00554-21-
Descrição: dc.descriptionFAPEMIG: APQ-02276-18-
Idioma: dc.languageen-
Relação: dc.relationBulletin of Materials Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectlipid composition-
Palavras-chave: dc.subjectmultilamellar vesicles-
Palavras-chave: dc.subjectNano/microparticulate systems-
Palavras-chave: dc.subjectquercetin-
Palavras-chave: dc.subjectrelease assays-
Título: dc.titleCharge and rigidity effects on the encapsulation of quercetin by multilamellar vesicles-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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