From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Paraná-
Autor(es): dc.contributorFederal University of Technology-Paraná-
Autor(es): dc.contributorPanama Fish Farm-
Autor(es): dc.contributorFederal University Curitiba-
Autor(es): dc.creatorYamamoto, Flávia Yoshie-
Autor(es): dc.creatorSouza, Angie Thaisa Costa-
Autor(es): dc.creatorPaula, Vinicius de Carvalho Soares de-
Autor(es): dc.creatorBeverari, Isabella-
Autor(es): dc.creatorGarcia, Juan Ramon Esquivel-
Autor(es): dc.creatorPadial, André Andian-
Autor(es): dc.creatorAbessa, Denis Moledo de Souza-
Data de aceite: dc.date.accessioned2025-08-21T15:49:32Z-
Data de disponibilização: dc.date.available2025-08-21T15:49:32Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-11-09-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.scitotenv.2022.157332-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240539-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240539-
Descrição: dc.descriptionSediments represent a major sink and also a main source of contaminants to aquatic environments. An environmental disaster from a mining dam breakage in 2015 in South-East Brazil re-suspended complex mixtures of chemicals deposited in the sediment, spreading contaminants along the Doce River Basin (DRB) major river course. While high levels of contaminants in sediment were well described, toxicological effects in aquatic organisms were poorly investigated. Thus, the effects of these potentially toxic chemicals were assessed in the present study through different endpoints (biochemical to populational levels) in fish embryos of the South-American silver catfish exposed to elutriates from different sites of the DRB. Despite no significant mortality observed, our results showed that exposure to the elutriates, especially those from the closest site to the dam collapse, caused higher deformities rates and DNA damage in the fish embryos than in the control group. Multivariate analysis showed that these sublethal effects may be related to the high levels of metals introduced by mining activities, compromising long-term survival and reproduction success. In addition, it was possible to observe the influence of other sources of pollutants along the river. According to our data, the mathematical model simulated a significant impact on the population density at longer-term exposure, for the sites that showed the most prominent toxicity responses. The fish embryo toxicity test proved to be an effective assay to assess the ecotoxicological effects of the pollutants from a major river contaminated by a mining dam collapse and showed that the survival rate per se was not a suitable endpoint to assess the toxicity of the pollutants. As a consequence, we contributed to shed a light on a potential underestimated impact of pollutants in sediments of the DRB on the native organisms at distinct biological levels of organizations.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa e Inovação do Espírito Santo-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionAgência Nacional de Águas-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University-
Descrição: dc.descriptionGraduation Program in Ecology and Conservation Federal University of Paraná-
Descrição: dc.descriptionDepartment of Chemistry and Biology Federal University of Technology-Paraná-
Descrição: dc.descriptionPanama Fish Farm-
Descrição: dc.descriptionAnalyses and Synthesis in Biodiversity Lab Botany Department Federal University Curitiba-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University-
Descrição: dc.descriptionFAPESP: 2016/15229-1-
Descrição: dc.descriptionAgência Nacional de Águas: 23038.028816/2016-41-
Descrição: dc.descriptionCNPq: 308533/2018-6-
Descrição: dc.descriptionCNPq: 308648/2021-8-
Idioma: dc.languageen-
Relação: dc.relationScience of the Total Environment-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiomarkers-
Palavras-chave: dc.subjectMining activities-
Palavras-chave: dc.subjectModeling-
Palavras-chave: dc.subjectSediments-
Palavras-chave: dc.subjectSublethal effects-
Palavras-chave: dc.subjectToxicity test-
Título: dc.titleFrom molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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