Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data

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Autor(es): dc.contributorUniversidade Federal dos Vales do Jequitinhonha e Mucuri-
Autor(es): dc.contributorFaculdade de Ciências Agrárias e Veterinárias-
Autor(es): dc.contributorUniversidade Federal de Santa Maria-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.creatorSantos, Cassiane Gomes dos-
Autor(es): dc.creatorSousa, Mariele Freitas-
Autor(es): dc.creatorVieira, João Inácio Gomes-
Autor(es): dc.creatorMorais, Luana Rafaela de-
Autor(es): dc.creatorFernandes, Aline Auxiliadora Silva-
Autor(es): dc.creatorLittiere, Thayssa de Oliveira-
Autor(es): dc.creatorOtto, Pamela Itajara-
Autor(es): dc.creatorMachado, Marco Antônio-
Autor(es): dc.creatorSilva, Marcos Vinicius Gualberto Barbosa-
Autor(es): dc.creatorBonafé, Cristina Moreira-
Autor(es): dc.creatorMagalhães, Ana Fabrícia Braga-
Autor(es): dc.creatorVerardo, Lucas Lima-
Data de aceite: dc.date.accessioned2025-08-21T21:07:05Z-
Data de disponibilização: dc.date.available2025-08-21T21:07:05Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/09712119.2022.2096035-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240511-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240511-
Descrição: dc.descriptionRhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5′ UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Animal Science Universidade Federal dos Vales do Jequitinhonha e Mucuri-
Descrição: dc.descriptionDepartment of Animal Science Faculdade de Ciências Agrárias e Veterinárias-
Descrição: dc.descriptionDepartment of Animal Science Universidade Federal de Santa Maria-
Descrição: dc.descriptionEmbrapa Gado de Leite-
Descrição: dc.descriptionFAPEMIG: APQ-01834-18-
Descrição: dc.descriptionCAPES: Financing Code 001-
Formato: dc.format460-470-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Animal Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbeef-
Palavras-chave: dc.subjectdairy-
Palavras-chave: dc.subjectEctoparasite-
Palavras-chave: dc.subjectgene networks-
Palavras-chave: dc.subjectgenome-
Palavras-chave: dc.subjectimmune system-
Título: dc.titleCandidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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