M2-2 gene as a new alternative molecular marker for phylogenetic, phylodynamic, and evolutionary studies of hRSV

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Alagoas (UFAL)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.creatorNunes, Denis Bruno S.M.-
Autor(es): dc.creatorVieira, Camila-
Autor(es): dc.creatorSá, Jéssica M.-
Autor(es): dc.creatorAraújo, Gabriela C.-
Autor(es): dc.creatorCaruso, Icaro P.-
Autor(es): dc.creatorSouza, Fátima P.-
Data de aceite: dc.date.accessioned2025-08-21T22:22:16Z-
Data de disponibilização: dc.date.available2025-08-21T22:22:16Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.virusres.2022.198850-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240426-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240426-
Descrição: dc.descriptionThe human Respiratory Syncytial Virus (hRSV) is the main causative agent of acute respiratory infections (ARI), such as pneumonia and bronchiolitis. One of the factors that lead to success in viral replication is the interaction of the M2-2 protein with the ribosomal complex. This interaction is responsible for the phase change of viral activity, acting as an inhibitor or inducer of viral replication, according to the concentration of mRNA. Based on the importance of M2-2 gene and protein have to viral physiology, we performed here evaluations of genetic diversity, phylogenetic reconstructions, phylodynamics, and selection test. Our results suggested an alternative way of classifying this virus in clades A and B, based on a new phylogenetic marker, the M2-2 gene. Therefore, our study is the first one to investigate the dynamics of the evolutionary diversification process of hRSV from the perspective of the M2-2 viral gene. In our study was also identified that the M2-2 gene is under the effect of purifying selection originated by population genetic bottlenecks. Therefore, the M2-2 gene demonstrated an interesting potential to be applied in evolutionary studies involving hRSV, recovering phylogenetic signals and traits of natural selection under the evolution of this virus.-
Descrição: dc.descriptionInstitute of Biological and Health Sciences Federal University of Alagoas (UFAL) Campus A.C. Simões, AL-
Descrição: dc.descriptionDepartment of Basic Sciences Faculty of Animal Science and Food Engineering University of São Paulo (USP), SP-
Descrição: dc.descriptionMultiuser Biomolecular Innovation Laboratory Department of Physics Letters and Exact Sciences Institute of Biosciences São Paulo State University “Júlio de Mesquita Filho” (UNESP), SP-
Descrição: dc.descriptionInstitute of Medical Biochemistry Leopoldo de Meis and National Center for Structural Biology and Bioimaging Federal University of Rio de Janeiro (UFRJ), RJ-
Descrição: dc.descriptionMultiuser Biomolecular Innovation Laboratory Department of Physics Letters and Exact Sciences Institute of Biosciences São Paulo State University “Júlio de Mesquita Filho” (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationVirus Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDivergence time-
Palavras-chave: dc.subjectEvolutionary dynamics-
Palavras-chave: dc.subjecthRSV-
Palavras-chave: dc.subjectM2-2-
Palavras-chave: dc.subjectMolecular phylogeny-
Palavras-chave: dc.subjectPurifying selection-
Título: dc.titleM2-2 gene as a new alternative molecular marker for phylogenetic, phylodynamic, and evolutionary studies of hRSV-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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