Epigenetic Mechanisms Involved in Inflammaging-Associated Hypertension

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad Maimónides-
Autor(es): dc.contributorUniversidad Nacional de Cuyo-
Autor(es): dc.contributorConsejo Nacional de Investigación Científica Y Tecnológica (IMBECU-CONICET)-
Autor(es): dc.creatorSimão, Vinícius Augusto-
Autor(es): dc.creatorFerder, León-
Autor(es): dc.creatorManucha, Walter-
Autor(es): dc.creatorChuffa, Luiz Gustavo A.-
Data de aceite: dc.date.accessioned2025-08-21T16:16:51Z-
Data de disponibilização: dc.date.available2025-08-21T16:16:51Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11906-022-01214-4-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240416-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240416-
Descrição: dc.descriptionPurpose of Review: This review summarizes the involvement of inflammaging in vascular damage with focus on the epigenetic mechanisms by which inflammaging-induced hypertension is triggered. Recent Findings: Inflammaging in hypertension is a complex condition associated with the production of inflammatory mediators by the immune cells, enhancement of oxidative stress, and tissue remodeling in vascular smooth muscle cells and endothelial cells. Cellular processes are numerous, including inflammasome assembly and cell senescence which may involve mitochondrial dysfunction, autophagy, DNA damage response, dysbiosis, and many others. More recently, a series of noncoding RNAs, mainly microRNAs, have been described as possessing epigenetic actions on the regulation of inflammasome-related hypertension, emerging as a promising therapeutic strategy. Summary: Although there are a variety of pharmacological agents that effectively regulate inflammaging-related hypertension, a deeper understanding of the epigenetic events behind the control of vessel deterioration is needed for the treatment or even to prevent the disease onset.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences UNESP - São Paulo State University, Zip Code: 510, P.O Box: 18618-689-
Descrição: dc.descriptionUniversidad Maimónides-
Descrição: dc.descriptionLaboratorio de Farmacología Experimental Básica Y Traslacional. Área de Farmacología Departamento de Patología Facultad de Ciencias Médicas Universidad Nacional de Cuyo-
Descrição: dc.descriptionInstituto de Medicina Y Biología Experimental de Cuyo Consejo Nacional de Investigación Científica Y Tecnológica (IMBECU-CONICET)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences UNESP - São Paulo State University, Zip Code: 510, P.O Box: 18618-689-
Idioma: dc.languageen-
Relação: dc.relationCurrent Hypertension Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEpigenetics-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectInflammasome; Elderly-
Palavras-chave: dc.subjectVascular inflammation; Inflammaging-
Título: dc.titleEpigenetic Mechanisms Involved in Inflammaging-Associated Hypertension-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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