Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBarbosa, Karla A.-
Autor(es): dc.creatorRodrigues, Isabella C.P.-
Autor(es): dc.creatorTamborlin, Letícia-
Autor(es): dc.creatorLuchessi, Augusto D.-
Autor(es): dc.creatorLopes, Éder S.N.-
Autor(es): dc.creatorGabriel, Laís P.-
Data de aceite: dc.date.accessioned2025-08-21T15:25:57Z-
Data de disponibilização: dc.date.available2025-08-21T15:25:57Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jmrt.2022.03.136-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240350-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240350-
Descrição: dc.descriptionPolymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle with antioxidant and wound-healing potential, as well as therapeutic action against diabetes, inflammation, and cancer. However, few techniques have been explored to efficiently produce curcumin-incorporated dressings on a large scale. Rotary jet spinning (RJS) is a membrane processing technique that has gained attention for its high production rate of fibers. In this study, we aimed to produce and characterize poly(L-lactic acid) (PLLA)-based RJS membranes incorporated with curcumin particles (PLLA-Curc) for wound-treatment suitability. We produced membranes with fiber diameters less than 10 μm. The membranes demonstrated thermal stability, a hydrophobic profile, adequate mechanical resistance for topical application, low degradation rates, and a marked release of curcumin over 6 h, followed by a continuous-release profile. In addition, PLLA and PLLA-Curc membranes showed cytocompatibility with fibroblasts. In summary, RJS is an efficient technique to obtain membranes incorporated with curcumin that have potential for wound treatment as non-adherent topical dressings.-
Descrição: dc.descriptionSchool of Applied Sciences University of Campinas, São Paulo-
Descrição: dc.descriptionSchool of Mechanical Engineering University of Campinas, São Paulo-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University, São Paulo-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University, São Paulo-
Formato: dc.format3273-3282-
Idioma: dc.languageen-
Relação: dc.relationJournal of Materials Research and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCentrifugal spinning-
Palavras-chave: dc.subjectDrug release-
Palavras-chave: dc.subjectPolylactic acid-
Palavras-chave: dc.subjectScaffold-
Palavras-chave: dc.subjectWound dressing-
Título: dc.titleRotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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