The BDNF-TrkB Pathway Acts Through Nucleus Accumbens D2 Expressing Neurons to Mediate Stress Susceptible Outcomes

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Autor(es): dc.contributorUniversity of Maryland School of Medicine-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Texas at El Paso-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorPennsylvania State College of Medicine-
Autor(es): dc.creatorPagliusi, Marco-
Autor(es): dc.creatorFranco, Daniela-
Autor(es): dc.creatorCole, Shannon-
Autor(es): dc.creatorMorais-Silva, Gessynger-
Autor(es): dc.creatorChandra, Ramesh-
Autor(es): dc.creatorFox, Megan E.-
Autor(es): dc.creatorIñiguez, Sergio D.-
Autor(es): dc.creatorSartori, Cesar R.-
Autor(es): dc.creatorLobo, Mary Kay-
Data de aceite: dc.date.accessioned2025-08-21T17:20:01Z-
Data de disponibilização: dc.date.available2025-08-21T17:20:01Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-06-02-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fpsyt.2022.854494-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240345-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240345-
Descrição: dc.descriptionBrain-derived neurotrophic factor (BDNF) has a critical role in stress response including neuropsychiatric disorders that are precipitated by stress, such as major depressive disorder (MDD). BDNF acts through its full-length BDNF receptor tyrosine kinase B (TrkB) to trigger a pro-plasticity effect. In contrast, the truncated isoform of the BDNF receptor (TrkB.t1) triggers an anti-plasticity effect. In stress outcomes, BDNF acting in the hippocampus has a stress resilience effect, and, inversely, in the nucleus accumbens (NAc), BDNF acts as a stress susceptible molecule. It is unknown if BDNF-TrkB acts on a specific NAc projection neuron, i.e., medium spiny neuron (MSN or spiny projection neuron), a subtype in stress outcomes. To determine this, we performed chronic social or vicarious witness defeat stress (CSDS or CWDS) in mice expressing TrkB.t1 in dopamine receptor 1 or 2 containing MSNs (D1- or D2-MSNs). Our results showed that TrkB.t1 overexpression in NAc D2-MSNs prevented the CSDS-induced social avoidance or other stress susceptible behaviors in male and female mice. We further showed that this overexpression in D2-MSNs blocked stress susceptible behavior induced by intra-NAc BDNF infusion. In contrast, our results demonstrate that overexpression of TrkB.t1 on NAc D1-MSNs facilitates the SDS susceptible behaviors. Our study provides enhanced details into the NAc cell subtype role of BDNF-TrkB signaling in stress outcomes.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Anatomy and Neurobiology University of Maryland School of Medicine-
Descrição: dc.descriptionDepartment of Structural and Functional Biology University of Campinas-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionDepartment of Psychology University of Texas at El Paso-
Descrição: dc.descriptionDepartment of Pharmacology University of São Paulo-
Descrição: dc.descriptionDepartment of Anesthesiology Pennsylvania State College of Medicine-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionFAPESP: 2018/05496-8-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Psychiatry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdepression-
Palavras-chave: dc.subjectmedium spiny neurons-
Palavras-chave: dc.subjectnucleus accumbens (NAc)-
Palavras-chave: dc.subjectresilience-
Palavras-chave: dc.subjectsocial defeat stress-
Palavras-chave: dc.subjectwitness defeat-
Título: dc.titleThe BDNF-TrkB Pathway Acts Through Nucleus Accumbens D2 Expressing Neurons to Mediate Stress Susceptible Outcomes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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