Role of platelet-derived growth factor c on endothelial dysfunction in cardiovascular diseases

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorPontificia Universidad Javeriana-
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Queensland-
Autor(es): dc.contributorUniversity Medical Center Groningen-
Autor(es): dc.contributorSchool of Medicine and Health Sciences-
Autor(es): dc.creatorGrismaldo, Adriana-
Autor(es): dc.creatorSobrevia, Luis-
Autor(es): dc.creatorMorales, Ludis-
Data de aceite: dc.date.accessioned2025-08-21T22:47:16Z-
Data de disponibilização: dc.date.available2025-08-21T22:47:16Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbagen.2022.130188-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240344-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240344-
Descrição: dc.descriptionLoss of endothelial function is a common feature to all cardiovascular diseases (CVDs). One of the risk factors associated with the development of CVDs is the hyperglycaemia that occurs in patients with metabolic disorders such as Type 1 and Type 2 diabetes mellitus. Hyperglycaemia causes endothelial dysfunction through increased production of reactive oxygen species (ROS) from different cellular sources leading to oxidative stress. Vascular endothelial growth factor (VEGF) is essential in the stimulation and maintenance of endothelial functional aspects and, although it can mitigate the impact of ROS, VEGF-mediated signalling is partially inhibited in diabetes mellitus. The search for therapeutic strategies that preserve, protect and improve the functions of the endothelium is of great relevance in the investigation of CVDs associated with hyperglycaemia. Platelet-derived growth factor C (PDGF-C) is a peptide with angiogenic properties, independent of VEGF, that stimulates angiogenesis and revascularization of ischemic tissue. In a diabetic mouse model, PDGF-C stimulates mature endothelial cell migration, angiogenesis, endothelial progenitor cell mobilization, and increased neovascularization, and protects blood vessels in a retinal degeneration model activating anti-apoptosis and proliferation signalling pathways in endothelial cells. This review summarizes the information on the damage that high D-glucose causes on endothelial function and the beneficial effects that PDGF-CC could exert in this condition.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionRijksuniversiteit Groningen-
Descrição: dc.descriptionPontificia Universidad Católica de Chile-
Descrição: dc.descriptionPontificia Universidad Javeriana-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico-
Descrição: dc.descriptionDepartamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)-
Descrição: dc.descriptionExperimental and Computational Biochemistry Group Faculty of Sciences Nutrition and Biochemistry Department Pontificia Universidad Javeriana, DC-
Descrição: dc.descriptionCellular and Molecular Physiology Laboratory Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland-
Descrição: dc.descriptionDepartment of Pathology and Medical Biology University of Groningen University Medical Center Groningen-
Descrição: dc.descriptionTecnologico de Monterrey Eutra The Institute for Obesity Research (IOR) School of Medicine and Health Sciences, Nuevo León-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionPontificia Universidad Javeriana: 00007731-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico: 1190316-
Descrição: dc.descriptionDepartamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS): 8306-
Idioma: dc.languageen-
Relação: dc.relationBiochimica et Biophysica Acta - General Subjects-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAngiogenesis-
Palavras-chave: dc.subjectCardiovascular diseases-
Palavras-chave: dc.subjectDiabetes mellitus-
Palavras-chave: dc.subjectHigh glucose-
Palavras-chave: dc.subjectPlatelet-derived growth factor C-
Título: dc.titleRole of platelet-derived growth factor c on endothelial dysfunction in cardiovascular diseases-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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