A new look at the role of nitric oxide in preeclampsia: Protein S-nitrosylation

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorUniversity of Mississippi Medical Center-
Autor(es): dc.creatorNunes, Priscila Rezeck-
Autor(es): dc.creatorPinheiro, Lucas Cezar-
Autor(es): dc.creatorMartins, Laisla Zanetoni-
Autor(es): dc.creatorDias-Junior, Carlos Alan-
Autor(es): dc.creatorPalei, Ana Carolina Taveiros-
Autor(es): dc.creatorSandrim, Valeria Cristina-
Data de aceite: dc.date.accessioned2025-08-21T16:51:44Z-
Data de disponibilização: dc.date.available2025-08-21T16:51:44Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.preghy.2022.05.008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240297-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240297-
Descrição: dc.descriptionThe formation of S-nitrosothiols (SNOs) occurs with the reaction of nitric oxide (NO) and free thiol groups in proteins. This process, called S-nitrosylation, allows NO to interfere with or even modulate a variety of cellular functions, culminating with the modification of protein trafficking, redox state, and cell cycle. Furthermore, NO plays a role in modulating a wide range of functions in endothelial cells specifically, including inflammation, apoptosis, permeability, migration, and cell growth. As such, NO acts as a mediator in several physiological processes. The interaction between endothelial nitric oxide synthase (eNOS) and proteins that are to be targeted for S-nitrosylation is a key determinant of the specificity of NO signaling. Deficits in the bioavailability of NO have been associated with pregnancy-related disorders, such as preeclampsia (PE). The study of S-nitrosylation in PE, as well as the identification of targeted proteins, may contribute to a better understanding of its pathophysiology and the development of drugs for the treatment of PE patients. In this review, we aimed to present the mechanism of S-nitrosylation, the regulatory pathways, and some proteins by which S-nitrosylation can modulate NO availability with a potential impact on PE.-
Descrição: dc.descriptionDepartment of Pharmacology and Biophysics Institute of Biosciences Sao Paulo State University (Unesp), São Paulo-
Descrição: dc.descriptionDepartment of Pharmacology Federal University of Santa Catarina (UFSC), Santa Catarina-
Descrição: dc.descriptionDepartment of Surgery School of Medicine University of Mississippi Medical Center-
Descrição: dc.descriptionDepartment of Pharmacology and Biophysics Institute of Biosciences Sao Paulo State University (Unesp), São Paulo-
Formato: dc.format14-20-
Idioma: dc.languageen-
Relação: dc.relationPregnancy Hypertension-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndothelial cells-
Palavras-chave: dc.subjectEndothelial dysfunction-
Palavras-chave: dc.subjectNitric Oxide-
Palavras-chave: dc.subjectNitrosylation-
Palavras-chave: dc.subjectNOS-
Palavras-chave: dc.subjectPreeclampsia-
Palavras-chave: dc.subjectS-nitrosothiols-
Palavras-chave: dc.subjectSNOs-
Título: dc.titleA new look at the role of nitric oxide in preeclampsia: Protein S-nitrosylation-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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