Impact of N-acetylcysteine (NAC) and calcium hydroxide intracanal medications in primary endodontic infection: a randomized clinical trial

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Maryland-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMartinho, Frederico C.-
Autor(es): dc.creatorCorazza, Bruna J. M.-
Autor(es): dc.creatorKhoury, Rayana D.-
Autor(es): dc.creatorOrozco, Esteban I. F.-
Autor(es): dc.creatorToia, Cassia C.-
Autor(es): dc.creatorMachado, Felipe P.-
Autor(es): dc.creatorValera, Marcia C.-
Data de aceite: dc.date.accessioned2025-08-21T17:06:27Z-
Data de disponibilização: dc.date.available2025-08-21T17:06:27Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-022-04585-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240267-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240267-
Descrição: dc.descriptionObjectives: This RCT investigated the impact of N-acetylcysteine (NAC) and calcium hydroxide [Ca(OH)2] intracanal medications (ICMs) in primary endodontic infection with apical periodontitis (PEIAP). Materials and methods: Thirty-six teeth with PEIAP were randomly divided into groups according to the ICM: NAC, Ca(OH)2 + saline solution (SSL), and Ca(OH)2 + 2% chlorhexidine-gel (2% CHX-gel) (all, n = 12). Root canal samples (RCSs) were collected before (s1) and after instrumentation (s2) and after 14 days of ICM (s3). Chemomechanical preparation (CMP) was performed with a Reciproc file and 2.5% NaOCl. Checkerboard DNA–DNA hybridization was used to assess 40 target bacteria species. Results: At s1, bacterial DNA was detected in 100% of RCSs (36/36). All 40 bacterial species were found in PEIAP. The mean number of species per RCS was 17.92 ± 13.18. The most frequent bacteria were S. mitis (65%), E. nodatum (63%), E. faecalis (63%), F. nucl sp vicentii (58%), T. forsythia (58%), and F. periodonticum (56%). CMP reduced the mean number of species per RCS to 6.8 ± 2.36 (p < 0.05). At s3, the intragroup analysis revealed a broader antimicrobial activity for Ca (OH)2 + 2% CHX-gel and NAC than Ca(OH)2 + SSL (p < 0.05). NAC eliminated 8/12 bacteria species resistant to both Ca (OH)2 ICMs, including P. micra, P. nigrescens, T. denticola, A. israelii, P. endodontalis, P. acnes, C. ochracea, and E. corrodens. Conclusions: Ca (OH)2 + 2% chlorhexidine gel (2% CHX gel) showed a greater bacterial elimination over the number of bacterial species; however, NAC eliminated 8/12 bacteria species resistant to both Ca (OH)2 ICMs (RBR-3xbnnn). Clinical relevance: The use of intracanal medication with a broad antimicrobial activity can optimize root canal disinfection. Ca(OH)2 + 2% CHX gel and NAC showed a broader antimicrobial activity than Ca(OH)2 + SSL against endodontic pathogens in primary root canal infection. Trial registration: Brazilian Registry of Clinical Trials (REBEC), No. RBR-3xbnnn.-
Descrição: dc.descriptionDivision of Endodontics Department of Advanced Oral Sciences and Therapeutics School of Dentistry University of Maryland, 650 West Baltimore Street, 6th floor, Suite 6253-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontic Division Institute of Science and Technology São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontic Division Institute of Science and Technology São Paulo State University - UNESP-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBacteria-
Palavras-chave: dc.subjectCalcium hydroxide-
Palavras-chave: dc.subjectIntracanal medication-
Palavras-chave: dc.subjectN-acetylcysteine-
Palavras-chave: dc.subjectNAC-
Palavras-chave: dc.subjectRoot canal-
Título: dc.titleImpact of N-acetylcysteine (NAC) and calcium hydroxide intracanal medications in primary endodontic infection: a randomized clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.