Enhanced Thrombin Generation Is Associated with Worse Left Ventricular Scarring after ST-Segment Elevation Myocardial Infarction: A Cohort Study

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Autor(es): dc.contributorNational University Heart Centre Singapore-
Autor(es): dc.contributorNational University of Singapore-
Autor(es): dc.contributorSavanamed-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorYishun Community Hospital-
Autor(es): dc.contributorJalan Hospital-
Autor(es): dc.contributorSarawak Heart Centre-
Autor(es): dc.contributorUniversity of Otago-
Autor(es): dc.contributorNational University Hospital-
Autor(es): dc.creatorSia, Ching-Hui-
Autor(es): dc.creatorTan, Sock-Hwee-
Autor(es): dc.creatorChan, Siew-Pang-
Autor(es): dc.creatorMarchesseau, Stephanie-
Autor(es): dc.creatorSim, Hui-Wen-
Autor(es): dc.creatorCarvalho, Leonardo-
Autor(es): dc.creatorChen, Ruth-
Autor(es): dc.creatorAmin, Nor Hanim Mohd-
Autor(es): dc.creatorFong, Alan Yean-Yip-
Autor(es): dc.creatorRichards, Arthur Mark-
Autor(es): dc.creatorYip, Christina-
Autor(es): dc.creatorChan, Mark Y.-
Data de aceite: dc.date.accessioned2025-08-21T19:22:30Z-
Data de disponibilização: dc.date.available2025-08-21T19:22:30Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph15060718-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240258-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240258-
Descrição: dc.descriptionAcute myocardial infarction (AMI) is associated with heightened thrombin generation. There are limited data relating to thrombin generation and left ventricular (LV) scarring and LV dilatation in post-MI LV remodeling. We studied 113 patients with ST-segment elevation myocardial infarction (STEMI) who had undergone primary percutaneous coronary intervention (PPCI) (n = 76) or pharmaco-invasive management (thrombolysis followed by early PCI, n = 37). Endogenous thrombin potential (ETP) was measured at baseline, 1 month and 6 months. Cardiovascular magnetic resonance imaging was performed at baseline and 6 months post-MI. Outcomes studied were an increase in scar change, which was defined as an increase in left ventricular infarct size of any magnitude detected by late gadolinium enhancement, adverse LV remodeling, defined as dilatation (increase) of left ventricular end-diastolic volume (LVEDV) by more than 20% and an increase in left ventricular ejection fraction (LVEF). The mean age was 55.19 ± 8.25 years and 91.2% were men. The baseline ETP was similar in the PPCI and pharmaco-invasive groups (1400.3 nM.min vs. 1334.1 nM.min, p = 0.473). Each 10-unit increase in baseline ETP was associated with a larger scar size (adjusted OR 1.020, 95% CI 1.002–1.037, p = 0.027). Baseline ETP was not associated with adverse LV remodeling or an increase in LVEF. There was no difference in scar size or adverse LV remodeling among patients undergoing PPCI vs. pharmaco-invasive management or patients receiving ticagrelor vs. clopidogrel. Enhanced thrombin generation after STEMI is associated with a subsequent increase in myocardial scarring but not LV dilatation or an increase in LVEF at 6 months post-MI.-
Descrição: dc.descriptionDepartment of Cardiology National University Heart Centre Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9-
Descrição: dc.descriptionDepartment of Medicine Yong Loo Lin School of Medicine National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 10-
Descrição: dc.descriptionNational University Heart Centre Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9-
Descrição: dc.descriptionYong Loo Lin School of Medicine National University of Singapore, 10 Medical Drive-
Descrição: dc.descriptionSavanamed, Calle Gran Vía, 30, Planta 10-
Descrição: dc.descriptionLaboratory of Genetics and Molecular Cardiology Heart Institute (InCor-HCFMUSP)-
Descrição: dc.descriptionCardiac Department Ferderal University of Sao Paulo State (UNIFESP)-
Descrição: dc.descriptionDepartment of Cardiology Woodlands Health Campus Tower E Level 5 Yishun Community Hospital, 2 Yishun Central 2-
Descrição: dc.descriptionClinical Research Centre Sarawak General Hospital Jalan Hospital-
Descrição: dc.descriptionDepartment of Cardiology Sarawak Heart Centre, Samarahan Expressway-
Descrição: dc.descriptionCardiovascular Research Institute National University of Singapore-
Descrição: dc.descriptionChristchurch Heart Institute Department of Medicine University of Otago, P.O. Box 4345-
Descrição: dc.descriptionDepartment of Laboratory Medicine National University Hospital, Main Building, Level 35 Lower Kent Ridge Road-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadverse ventricular remodeling-
Palavras-chave: dc.subjectcardiovascular magnetic resonance imaging-
Palavras-chave: dc.subjectpercutaneous coronary intervention-
Palavras-chave: dc.subjectST-segment elevation myocardial infarction-
Palavras-chave: dc.subjectthrombolysis-
Título: dc.titleEnhanced Thrombin Generation Is Associated with Worse Left Ventricular Scarring after ST-Segment Elevation Myocardial Infarction: A Cohort Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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