Assessment of the remineralisation induced by contemporary ion-releasing materials in mineral-depleted dentine

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Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorCEU Universities-
Autor(es): dc.contributorUniversità Degli Studi Di Milano-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPires, Paula Maciel-
Autor(es): dc.creatorIonescu, Andrei Cristian-
Autor(es): dc.creatorPérez-Gracia, Maria Teresa-
Autor(es): dc.creatorVezzoli, Elena-
Autor(es): dc.creatorSoares, Igor Paulino Mendes-
Autor(es): dc.creatorBrambilla, Eugenio-
Autor(es): dc.creatorNeves, Aline de Almeida-
Autor(es): dc.creatorSauro, Salvatore-
Data de aceite: dc.date.accessioned2025-08-21T16:58:26Z-
Data de disponibilização: dc.date.available2025-08-21T16:58:26Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-022-04569-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240207-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240207-
Descrição: dc.descriptionObjectives: Evaluate the ability of current ion-releasing materials to remineralise bacteria-driven artificial caries lesions. Materials and methods: Standardised class I cavities were obtained in 60 extracted human molars. Specimens underwent a microbiological cariogenic protocol (28 days) to generate artificial caries lesions and then were randomly divided into four restorative groups: adhesive + composite (negative control); glass ionomer cement (GIC); calcium silicate cement (MTA); and resin-modified calcium silicate cement (RMTA). Microhardness analysis (ΔKHN) was performed on 40 specimens (10/group, t = 30 days, 45 days, 60 days in artificial saliva, AS). Micro-CT scans were acquired (3/group, t = 0 days, 30 days, and 90 days in AS). Confocal microscopy was employed for interfacial ultra-morphology analysis (2/group, t = 0 days and 60 days in AS). Additional specimens were prepared and processed for scanning electron microscopy (SEM) and FTIR (n = 3/group + control) to analyse the ability of the tested materials to induce apatite formation on totally demineralised dentine discs (60 days in AS). Statistical analyses were performed with a significance level of 5%. Results: Adhesive + composite specimens showed the lowest ΔKHN values and the presence of gaps at the interface when assessed through micro-CT even after storage in AS. Conversely, all the tested ion-releasing materials presented an increase in ΔKHN after storage (p < 0.05), while MTA best reduced the demineralised artificial carious lesions gap at the interface. MTA and RMTA also showed apatite deposition on totally demineralised dentine surfaces (SEM and FTIR). Conclusions: All tested ion-releasing materials expressed mineral precipitation in demineralised dentine. Additionally, calcium silicate-based materials induced apatite precipitation and hardness recovery of artificial carious dentine lesions over time. Clinical relevance: Current ion-releasing materials can induce remineralisation of carious dentine. MTA shows enhanced ability of nucleation/precipitation of hydroxyapatite compared to RMTA and GIC, which may be more appropriate to recover severe mineral-depleted dentine.-
Descrição: dc.descriptionDepartment of Pediatric Dentistry Universidade Federal Do Rio de Janeiro-
Descrição: dc.descriptionDental Biomaterials and Minimally Invasive Dentistry Department of Dentistry Cardenal Herrera-CEU University CEU Universities-
Descrição: dc.descriptionOral Microbiology and Biomaterials Laboratory Department of Biomedical Surgical and Dental Sciences Università Degli Studi Di Milano-
Descrição: dc.descriptionMicrobiology Departamento de Farmacia Cardenal Herrera-CEU University CEU Universities-
Descrição: dc.descriptionDepartment of Biomedical Sciences for Health Università Degli Studi Di Milano-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University UNESP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University UNESP-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDental biomaterials-
Palavras-chave: dc.subjectDentine replacement materials-
Palavras-chave: dc.subjectIon-releasing materials-
Palavras-chave: dc.subjectRemineralisation-
Palavras-chave: dc.subjectRestorative dentistry-
Título: dc.titleAssessment of the remineralisation induced by contemporary ion-releasing materials in mineral-depleted dentine-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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