Chalcones with potential antibacterial and antibiofilm activities against periodontopathogenic bacteria

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Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversity of Franca-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSatokata, Alessandra Akemi Cury-
Autor(es): dc.creatorSouza, Jonathan Henrique-
Autor(es): dc.creatorSilva, Luana Luiza Oliveira-
Autor(es): dc.creatorSantiago, Mariana Brentini-
Autor(es): dc.creatorRamos, Salvador Boccaletti-
Autor(es): dc.creatorAssis, Leticia Ribeiro de-
Autor(es): dc.creatorTheodoro, Reinaldo dos Santos-
Autor(es): dc.creatorOliveira, Lígia Rodrigues e-
Autor(es): dc.creatorRegasini, Luis Octavio-
Autor(es): dc.creatorMartins, Carlos Henrique Gomes-
Data de aceite: dc.date.accessioned2025-08-21T20:25:38Z-
Data de disponibilização: dc.date.available2025-08-21T20:25:38Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.anaerobe.2022.102588-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240154-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240154-
Descrição: dc.descriptionObjectives: Periodontitis is a pathology resulting from complex interaction of microorganisms in the dental biofilm with the host's immune system. Increased use of antibiotics associated with their inappropriate use has increased resistance levels in anaerobic bacteria. Therefore, identifying new antimicrobial compounds, such as chalcones, is urgent. This study evaluates the antibacterial activity and the antibiofilm activity of 15 chalcones against the periodontopathogenic bacteria Prevotella nigrescens (ATCC 33563), P. oralis (ATCC 33269), Peptostreptococcus anaerobius (ATCC 27337), Actinomyces viscosus (ATCC 43146), Porphyromonas asaccharolytica (ATCC 25260), and Fusobacterium nucleatum (ATCC 25586). Methods: The compounds were evaluated by minimum inhibitory concentration (MIC) and minimum biofilm inhibitory concentration (MBIC) tests. Results: Compounds 1–6 showed good antibacterial and antibiofilm activities against most of the evaluated bacteria: MIC was lower than or equal to 6.25 μg/mL, biofilm biomass was reduced by 95%, and the compounds at concentrations between 0.78 and 100 μg/mL totally inhibited cell viability. Among the tested chalcones, 3 stood out: it was effective against all the bacteria, as revealed by the MIC and MBIC results. Conclusions: Our results have consolidated a base for the development of new studies on the effects of the tested chalcones as agents to combat and to prevent periodontitis.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Antimicrobial Testing (LEA) Institute of Biomedical Sciences Federal University of Uberlândia, MG-
Descrição: dc.descriptionUniversity of Franca, SP-
Descrição: dc.descriptionLaboratory of Antibiotics and Chemotherapeutics (LAQ) Department of Chemistry and Environmental Sciences São Paulo State University, SP-
Descrição: dc.descriptionLaboratory of Antibiotics and Chemotherapeutics (LAQ) Department of Chemistry and Environmental Sciences São Paulo State University, SP-
Descrição: dc.descriptionFAPESP: 2014/18330–0-
Descrição: dc.descriptionFAPESP: 2018/15083–2-
Idioma: dc.languageen-
Relação: dc.relationAnaerobe-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnaerobic bacteria-
Palavras-chave: dc.subjectAntibacterial activity-
Palavras-chave: dc.subjectAntibiofilm activity-
Palavras-chave: dc.subjectChalcone-
Palavras-chave: dc.subjectPeriodontitis-
Título: dc.titleChalcones with potential antibacterial and antibiofilm activities against periodontopathogenic bacteria-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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