Polymicrobial biofilms related to dental implant diseases: unravelling the critical role of extracellular biofilm matrix

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Connecticut Health Center-
Autor(es): dc.contributorUniversity Ceuma (UNICEUMA)-
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorDental Science School (Faculdade de Ciências Odontológicas - FCO)-
Autor(es): dc.contributorGuarulhos University-
Autor(es): dc.contributorUniversity of Pittsburgh-
Autor(es): dc.creatorCosta, Raphael C.-
Autor(es): dc.creatorBertolini, Martinna-
Autor(es): dc.creatorOliveira, Barbara E. Costa-
Autor(es): dc.creatorNagay, Bruna E.-
Autor(es): dc.creatorDini, Caroline-
Autor(es): dc.creatorBenso, Bruna-
Autor(es): dc.creatorKlein, Marlise I.-
Autor(es): dc.creatorBarāo, Valentim A. R.-
Autor(es): dc.creatorSouza, Joāo Gabriel S.-
Data de aceite: dc.date.accessioned2025-08-21T19:58:39Z-
Data de disponibilização: dc.date.available2025-08-21T19:58:39Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/1040841X.2022.2062219-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240141-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240141-
Descrição: dc.descriptionBiofilms are complex tri-dimensional structures that encase microbial cells in an extracellular matrix comprising self-produced polymeric substances. The matrix rich in extracellular polymeric substance (EPS) contributes to the unique features of biofilm lifestyle and structure, enhancing microbial accretion, biofilm virulence, and antimicrobial resistance. The role of the EPS matrix of biofilms growing on biotic surfaces, especially dental surfaces, is largely unravelled. To date, there is a lack of a broad overview of existing literature concerning the relationship between the EPS matrix and the dental implant environment and its role in implant-related infections. Here, we discuss recent advances in the critical role of the EPS matrix on biofilm growth and virulence on the dental implant surface and its effect on the etiopathogenesis and progression of implant-related infections. Similar to other biofilms associated with human diseases/conditions, EPS-enriched biofilms on implant surfaces promote microbial accumulation, microbiological shift, cross-kingdom interaction, antimicrobial resistance, biofilm virulence, and, consequently, peri-implant tissue damage. But intriguingly, the protagonism of EPS role on implant-related infections and the development of matrix-target therapeutic strategies has been neglected. Finally, we highlight the need for more in-depth analyses of polymicrobial interactions within EPS matrix and EPS-targeting technologies' rationale for disrupting the complex biofilm microenvironment with more outstanding translation to implant applications in the near future.-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Oral Health and Diagnostic Sciences University of Connecticut Health Center-
Descrição: dc.descriptionGraduate Program in Dentistry University Ceuma (UNICEUMA)-
Descrição: dc.descriptionSchool of Dentistry Faculty of Medicine Pontificia Universidad Católica de Chile, CA-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University-
Descrição: dc.descriptionDental Science School (Faculdade de Ciências Odontológicas - FCO)-
Descrição: dc.descriptionDental Research Division Guarulhos University-
Descrição: dc.descriptionDepartment of Periodontics and Preventive Dentistry School of Dental Medicine University of Pittsburgh-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationCritical Reviews in Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectExtracellular matrix-
Palavras-chave: dc.subjectextracellular polymeric substances (EPS)-
Palavras-chave: dc.subjectmicroenvironments-
Palavras-chave: dc.subjectpolymicrobial biofilm-
Palavras-chave: dc.subjectspatial organisation-
Palavras-chave: dc.subjectvirulence-
Título: dc.titlePolymicrobial biofilms related to dental implant diseases: unravelling the critical role of extracellular biofilm matrix-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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