Efficiency of the removal of tetraethyl pyrophosphate (TEPP) pesticide in water: use of cork granules as a natural adsorbent on acetylcholinesterase activity in neuronal PC12 cell

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do ABC (UFABC)-
Autor(es): dc.creatorMalheiros, Fernanda Blini Marengo-
Autor(es): dc.creatorVicente, Eduardo Festozo-
Autor(es): dc.creatorMorales, Angélica Gois-
Autor(es): dc.creatorAlberto-Silva, Carlos-
Data de aceite: dc.date.accessioned2025-08-21T16:07:15Z-
Data de disponibilização: dc.date.available2025-08-21T16:07:15Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/03601234.2022.2077608-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240107-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240107-
Descrição: dc.descriptionTetraethyl pyrophosphate (TEPP) is an organophosphate pesticide that irreversibly inhibits acetylcholinesterase (AChE). Cork powder or granules have been recommended as a sustainable sorbent to remove pesticides from water. In the present study, we evaluated the effectiveness of removing TEPP from water using wine corks to obtain cork granules as natural adsorbent, analyzing the TEPP effects on AChE activity in commercial enzyme from Electrophorus electricus and secreted by neuronal PC12 cells. TEPP inhibited AChE activity in a concentration-dependent manner. For the first time, we showed that different concentrations of TEPP diluted in water after adsorption experiments using cork granules decreased TEPP's inhibitory effects on AChE activity in commercial enzyme and neuronal PC12 cell culture medium. Our results suggest that the optimum removal of TEPP from water by corks was 91.4 ± 4.0%. Overall, the findings support the hypothesis that cork granules can be used to remediate pesticide-contaminated environments, such as those contaminated by organophosphate pesticides, and demonstrate a new application of a biochemical assay on AChE activity using a commercial enzyme or secreted by neuronal PC12 cells in culture as a possible methodologic strategy for evaluating the success of TEPP removal from water.-
Descrição: dc.descriptionPostgraduate Course in Agribusiness and Development Research Group on Environmental Management and Education (PGEA) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biosystems Engineering São Paulo State University (UNESP) School of Science and Engineering, SP-
Descrição: dc.descriptionResearch Group on Environmental Management and Education (PGEA) São Paulo State University (UNESP) Department of Management Development and Tecnology, SP-
Descrição: dc.descriptionNatural and Humanities Sciences Center Experimental Morphophysiology Laboratory Federal University of ABC (UFABC), SP-
Descrição: dc.descriptionPostgraduate Course in Agribusiness and Development Research Group on Environmental Management and Education (PGEA) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biosystems Engineering São Paulo State University (UNESP) School of Science and Engineering, SP-
Descrição: dc.descriptionResearch Group on Environmental Management and Education (PGEA) São Paulo State University (UNESP) Department of Management Development and Tecnology, SP-
Formato: dc.format554-560-
Idioma: dc.languageen-
Relação: dc.relationJournal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAChE inhibition-
Palavras-chave: dc.subjectAdsorption-
Palavras-chave: dc.subjectlow-cost materials-
Palavras-chave: dc.subjectorganophosphates-
Palavras-chave: dc.subjectsustainable sorbent-
Título: dc.titleEfficiency of the removal of tetraethyl pyrophosphate (TEPP) pesticide in water: use of cork granules as a natural adsorbent on acetylcholinesterase activity in neuronal PC12 cell-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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