Immunometabolism-fit: How exercise and training can modify T cell and macrophage metabolism in health and disease

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorOkanagan Campus-
Autor(es): dc.contributorCNRS 5261-
Autor(es): dc.contributorUniversity of Canberra-
Autor(es): dc.contributorFaculty of Sports Science and Physical Education-
Autor(es): dc.contributorUniversidad Autónoma de Baja California-
Autor(es): dc.contributorJustus Liebig University Giessen-
Autor(es): dc.creatorRosa-Neto, José Cesar-
Autor(es): dc.creatorLira, Fábio Santos-
Autor(es): dc.creatorLittle, Jonathan Peter-
Autor(es): dc.creatorLandells, Graham-
Autor(es): dc.creatorIslam, Hashim-
Autor(es): dc.creatorChazaud, Bénédicte-
Autor(es): dc.creatorPyne, David B.-
Autor(es): dc.creatorTeixeira, Ana Maria-
Autor(es): dc.creatorBatatinha, Helena-
Autor(es): dc.creatorMoura Antunes, Barbara-
Autor(es): dc.creatorGuerra Minuzzi, Luciele-
Autor(es): dc.creatorPalmowski, Jana-
Autor(es): dc.creatorSimpson, Richard J.-
Autor(es): dc.creatorKrüger, Karsten-
Data de aceite: dc.date.accessioned2025-08-21T21:13:26Z-
Data de disponibilização: dc.date.available2025-08-21T21:13:26Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240027-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240027-
Descrição: dc.descriptionBACKGROUND: The term immunometabolism describes cellular and molecular metabolic processes that control the immune system and the associated immune responses. Acute exercise and regular physical activity have a substantial influence on the metabolism and the immune system, so that both processes are closely associated and influence each other bidirectionally. SCOPE OF REVIEW: We limit the review here to focus on metabolic phenotypes and metabolic plasticity of T cells and macrophages to describe the complex role of acute exercise stress and regular physical activity on these cell types. The metabolic and immunological consequences of the social problem of inactivity and how, conversely, an active lifestyle can break this vicious circle, are then described. Finally, these aspects are evaluated against the background of an aging society. MAJOR CONCLUSIONS: T cells and macrophages show high sensitivity to changes in their metabolic environment, which indirectly or directly affects their central functions. Physical activity and sedentary behaviour have an important influence on metabolic status, thereby modifying immune cell phenotypes and influencing immunological plasticity. A detailed understanding of the interactions between acute and chronic physical activity, sedentary behaviour, and the metabolic status of immune cells, can help to target the dysregulated immune system of people who live in a much too inactive society.-
Descrição: dc.descriptionImmunometabolism Research Group Department of Cell Biology and Development Institute of Biomedical Sciences 1 University of São Paulo (ICB1-USP)-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Health and Exercise Sciences University of British Columbia Okanagan Campus-
Descrição: dc.descriptionInstitut NeuroMyoGene Unité Physiopathologie et Génétique du Neurone et du Muscle Univ Lyon CNRS 5261, Université Claude Bernard Lyon 1-
Descrição: dc.descriptionResearch Institute for Sport and Exercise University of Canberra-
Descrição: dc.descriptionUniversity of Coimbra Research Center for Sports and Physical Activity Faculty of Sports Science and Physical Education-
Descrição: dc.descriptionUniversidad Autónoma de Baja California, Facultad de Deportes Campus Ensenada-
Descrição: dc.descriptionDepartment of Exercise Physiology and Sports Therapy Institute of Sports Science Justus Liebig University Giessen-
Descrição: dc.descriptionSchool of Nutritional Sciences and Wellness; Department of Pediatrics; Department of Immunobiology, The University of Arizona, Tucson, AZ, USA-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education São Paulo State University (UNESP)-
Formato: dc.format29-46-
Idioma: dc.languageen-
Relação: dc.relationExercise immunology review-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectExercise-
Palavras-chave: dc.subjectImmune System-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectMetabolism-
Palavras-chave: dc.subjectSedentary behavior-
Título: dc.titleImmunometabolism-fit: How exercise and training can modify T cell and macrophage metabolism in health and disease-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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