Melatonin: A mitochondrial resident with a diverse skill set

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUT Health-
Autor(es): dc.contributorInstituto Mexicano del Seguro Social-
Autor(es): dc.contributorFAMERP-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorReiter, Russel J.-
Autor(es): dc.creatorSharma, Ramaswamy-
Autor(es): dc.creatorRosales-Corral, Sergio-
Autor(es): dc.creatorZuccari, Debora Aparecida Pires de Campos-
Autor(es): dc.creatorChuffa, Luiz Gustavo de Almeida-
Data de aceite: dc.date.accessioned2025-08-21T17:44:16Z-
Data de disponibilização: dc.date.available2025-08-21T17:44:16Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-07-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2022.120612-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240021-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240021-
Descrição: dc.descriptionMelatonin is an ancient molecule that originated in bacteria. When these prokaryotes were phagocytized by early eukaryotes, they eventually developed into mitochondria and chloroplasts. These new organelles retained the melatonin synthetic capacity of their forerunners such that all present-day animal and plant cells may produce melatonin in their mitochondria and chloroplasts. Melatonin concentrations are higher in mitochondria than in other subcellular compartments. Isolated mouse oocyte mitochondria form melatonin when they are incubated with serotonin, a necessary precursor. Oocyte mitochondria subsequently give rise to these organelles in all adult vertebrate cells where they continue to synthesize melatonin. The enzymes that convert serotonin to melatonin, i.e., arylalkylamine-N-acetyltransferase (AANAT) and acetylserotonin-O-methyltransferase, have been identified in brain mitochondria which, when incubated with serotonin, also form melatonin. Melatonin is a potent antioxidant and anti-cancer agent and is optimally positioned in mitochondria to aid in the maintenance of oxidative homeostasis and to reduce cancer cell transformation. Melatonin stimulates the transfer of mitochondria from healthy cells to damaged cells via tunneling nanotubes. Melatonin also regulates the major NAD+-dependent deacetylase, sirtuin 3, in the mitochondria. Disruptions of mitochondrial melatonin synthesis may contribute to a number of mitochondria-related diseases, as discussed in this review.-
Descrição: dc.descriptionDepartment of Cell Systems and Anatomy UT Health-
Descrição: dc.descriptionCentro de Investigacion Biomedica de Occidente Instituto Mexicano del Seguro Social, Jalisco-
Descrição: dc.descriptionCancer Molecular Research Laboratory Department of Molecular Biology FAMERP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences UNESP-São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences UNESP-São Paulo State University, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcetyl coenzyme a-
Palavras-chave: dc.subjectcancer-
Palavras-chave: dc.subjectPyruvate metabolism-
Palavras-chave: dc.subjectsepsis-
Palavras-chave: dc.subjectSIRT3-
Palavras-chave: dc.subjectTunneling nanotubes-
Título: dc.titleMelatonin: A mitochondrial resident with a diverse skill set-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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