Development and in vitro cytotoxicity assessment of nanoemulsified lawsone

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Autor(es): dc.contributorFederal University of the São Francisco Valley (UNIVASF)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPaul Sabatier University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSousa, Rosa Maria G.-
Autor(es): dc.creatorRodrigues, Fernando V. S.-
Autor(es): dc.creatorMedrado, Bárbara L. S.-
Autor(es): dc.creatorOliveira, Louise M.-
Autor(es): dc.creatorPereira, Ícaro G. M.-
Autor(es): dc.creatorAmantino, Camila F.-
Autor(es): dc.creatorGoto, Patrícia L.-
Autor(es): dc.creatorBlanzat, Muriel-
Autor(es): dc.creatorPrimo, Fernando L.-
Autor(es): dc.creatorTedesco, Antonio C.-
Autor(es): dc.creatorSiqueira-Moura, Marigilson P.-
Data de aceite: dc.date.accessioned2025-08-21T17:14:35Z-
Data de disponibilização: dc.date.available2025-08-21T17:14:35Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11696-022-02242-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/240016-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/240016-
Descrição: dc.descriptionLawsone is a biomolecule that belongs to the naphthoquinone class found in henna leaves. This quinone is widely used in cosmetic products being considered the oldest coloring agent applied for dyeing hair. Moreover, biological activities have been attributed to lawsone such as antibacterial, antifungal, and anticancer. However, these activities are mostly limited due to its low aqueous solubility and chemical instability. In this context, this study aimed to develop nanoemulsion containing lawsone (NE-law) and assess its in vitro cytotoxicity against cervical carcinoma cells. Emulsion phase inversion method was used to prepare nanoemulsion formulations (NE1, NE2, NE3, NE4, and NE-law). Following the formulation development, NE1 formulation was chosen to incorporate lawsone, presenting average droplet size about 45 nm with narrow size distribution (PdI < 0.1) and negative zeta potential (≈ − 13 mV). In TEM analyses, droplets were visualized with irregular spherical shapes, high homogeneity, and without aggregation. The incorporation efficiency of lawsone into NE was higher than 90%, and in vitro release profile of this naphthoquinone from formulation was gradual and regular throughout the experiment. Nanoemulsified lawsone improved in vitro cytotoxicity on cervical carcinoma cells compared to free lawsone. Therefore, we prepared a stable lawsone-loaded NE using a reproducible emulsification method.-
Descrição: dc.descriptionFundação Universidade Federal do Vale do São Francisco-
Descrição: dc.descriptionFundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionGraduate Program in Biosciences (PPGB) Federal University of the São Francisco Valley (UNIVASF), Pernambuco-
Descrição: dc.descriptionCollege of Pharmaceutical Sciences (CFARM) Federal University of the São Francisco Valley (UNIVASF), PE-
Descrição: dc.descriptionDepartment of Engineering of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionIMRCP Laboratory UMR 5623 CNRS Paul Sabatier University-
Descrição: dc.descriptionDepartment of Chemistry Center of Nanotechnology and Tissue Engineering -Photobiology and Photomedicine Research Group Faculty of Philosophy Sciences and Letters of Ribeirão Preto (FFCLRP) University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionDepartment of Engineering of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFundação Universidade Federal do Vale do São Francisco: 198/2019-
Descrição: dc.descriptionFundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco: BIC-1384-4.03/20-
Descrição: dc.descriptionFundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco: IBPG-0968-4.03/14-
Descrição: dc.descriptionCAPES: Ph-C 859-15-
Formato: dc.format5043-5050-
Idioma: dc.languageen-
Relação: dc.relationChemical Papers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectEPI method-
Palavras-chave: dc.subjectLawsone-
Palavras-chave: dc.subjectNanoemulsion-
Título: dc.titleDevelopment and in vitro cytotoxicity assessment of nanoemulsified lawsone-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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