Influences of Solubility and Vehicle Carriers on Eriodictyol Pharmacokinetics in Rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorAgricultural Research Service-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorManthey, John A.-
Autor(es): dc.creatorFerreira, Paula S.-
Autor(es): dc.creatorCesar, Thais B.-
Data de aceite: dc.date.accessioned2025-08-21T17:34:13Z-
Data de disponibilização: dc.date.available2025-08-21T17:34:13Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-04-20-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.jafc.2c00319-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/239902-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/239902-
Descrição: dc.descriptionIn this study, the pharmacokinetics of oral doses of eriodictyol in 1% sodium carboxymethylcellulose and in saline/PEG400/Tween80 (75/20/5, v/v/v) in rats were compared. The pharmacokinetics of eriocitrin administered as a dissolved solution in water were also characterized. Metabolites of eriodictyol and eriocitrin in whole blood consisted mainly of eriodictyol, homoeriodictyol, and hesperetin glucuronides and ring-fission metabolites. In whole blood, no free nonconjugated flavanone aglycones were detected. Significant differences were observed in the pharmacokinetics of eriodictyol administered as a suspension in 1% sodium carboxymethylcellulose versus administration as a dissolved solution in saline/PEG400/Tween80 (75/20/5, v/v/v). At a dose of 25 mg kg-1eriodictyol administered with 1% sodium carboxymethylcellulose, a biphasic pharmacokinetic curve was observed, while only a single concentration peak was observed following an administration of 25 mg kg-1eriodictyol dissolved in saline/PEG400/Tween80 (75/20/5, v/v/v). For all trials, the pharmacokinetics of eriodictyol differed from those of eriocitrin dissolved in water.-
Descrição: dc.descriptionU.S. Horticultural Research Laboratory U.S. Department of Agriculture Agricultural Research Service, 2001 S. Rock Road-
Descrição: dc.descriptionLaboratory of Nutrition School of Pharmaceutical Sciences São Paulo State University - Unesp, SP-
Descrição: dc.descriptionLaboratory of Nutrition School of Pharmaceutical Sciences São Paulo State University - Unesp, SP-
Formato: dc.format4667-4676-
Idioma: dc.languageen-
Relação: dc.relationJournal of Agricultural and Food Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjecteriocitrin-
Palavras-chave: dc.subjectflavanones-
Palavras-chave: dc.subjectglucuronides-
Palavras-chave: dc.subjectmetabolites-
Palavras-chave: dc.subjectsulfated metabolites-
Título: dc.titleInfluences of Solubility and Vehicle Carriers on Eriodictyol Pharmacokinetics in Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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