Immunolabelling of Acetylated Histones 3 and 4 and Histone Deacetylases 1, 2 and 6 in Canine Soft Tissue Sarcomas

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Vila Velha-
Autor(es): dc.contributorLife – Oncologia Veterinária-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAutonomous Veterinarian-
Autor(es): dc.contributorHU-Univasf-
Autor(es): dc.contributorVETPAT Pathology and Molecular Biology Laboratory-
Autor(es): dc.creatorSena, Bruna V.-
Autor(es): dc.creatorHorta, Rodrigo S.-
Autor(es): dc.creatorSenhorello, Igor L.S.-
Autor(es): dc.creatorMatiz, Oscar R.S.-
Autor(es): dc.creatorCanavari, Isabela C.-
Autor(es): dc.creatorSouza, Larissa M.-
Autor(es): dc.creatorFerreira, Marília G.P.A.-
Autor(es): dc.creatorSueiro, Felipe A.R.-
Autor(es): dc.creatorCosta, Mirela T.-
Autor(es): dc.creatorNardi, Andrigo B. de[UNESP]-
Data de aceite: dc.date.accessioned2025-08-21T21:04:20Z-
Data de disponibilização: dc.date.available2025-08-21T21:04:20Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jcpa.2022.03.001-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/239877-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/239877-
Descrição: dc.descriptionThe objective of this study was to investigate the immunolabelling of acetylated histones and histone desacetylase (HDAC) enzymes in canine soft tissue sarcomas (STSs) and to correlate them with histological and clinical features in order to identify possible prognostic and therapeutic targets in these neoplasms. Fifteen canine STS samples were evaluated and were submitted to immunohistochemistry for acetylated histones 3 (H3) and 4 (H4) and deacetylating enzymes (HDAC1, HDAC2 and HDAC6). Intense immunolabelling of H4 was seen in comparison with H3. A strong positive correlation was observed between the H3 intensity score and the number of mitotic figures (P = 0.004, r = 0.7). Intense immunolabelling of HDAC1 was found in comparison to the expression of HDAC2 and HDAC6 in the evaluated STSs. This finding suggests that HDAC1 may be a potential target for HDAC inhibitors in STSs in dogs.-
Descrição: dc.descriptionDepartment of Veterinary Medicine and Surgery Veterinay School Universidade Federal de Minas Gerais, MG-
Descrição: dc.descriptionDepartment of Veterinary Medicine Universidade Vila Velha, ES-
Descrição: dc.descriptionAutonomous Veterinarian Life – Oncologia Veterinária-
Descrição: dc.descriptionDepartment of Clinical and Veterinary Surgery College of Agricultural and Veterinary Sciences Universidade Estadual Paulista Júlio de Mesquita Filho UNESP, SP-
Descrição: dc.descriptionAutonomous Veterinarian, ES-
Descrição: dc.descriptionVeterinary Hospital Universidade Federal do Vale do São Francisco HU-Univasf, PE-
Descrição: dc.descriptionVETPAT Pathology and Molecular Biology Laboratory, SP-
Descrição: dc.descriptionDepartment of Clinical and Veterinary Surgery College of Agricultural and Veterinary Sciences Universidade Estadual Paulista Júlio de Mesquita Filho UNESP, SP-
Formato: dc.format51-58-
Idioma: dc.languageen-
Relação: dc.relationJournal of Comparative Pathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcanine-
Palavras-chave: dc.subjectepigenetic-
Palavras-chave: dc.subjecthistones-
Palavras-chave: dc.subjectmesenchymal neoplasia-
Título: dc.titleImmunolabelling of Acetylated Histones 3 and 4 and Histone Deacetylases 1, 2 and 6 in Canine Soft Tissue Sarcomas-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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