Increased incidence of inflammatory bowel disease on etanercept in juvenile idiopathic arthritis regardless of concomitant methotrexate use

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorWilhelmina Children's Hospital-
Autor(es): dc.contributorIRCCS Istituto Giannina Gaslini-
Autor(es): dc.contributorUniversità degli Studi di Genova-
Autor(es): dc.contributorAffiliate of Vilnius University Hospital Santaros Clinic-
Autor(es): dc.contributorVilnius University-
Autor(es): dc.contributorAlexandru Ioan Cuza University of Iasi-
Autor(es): dc.contributorCharles University in Prague-
Autor(es): dc.contributorSpedali Civili-
Autor(es): dc.contributorInstitute of Rheumatology of Belgrade-
Autor(es): dc.contributorRio de Janeiro State University-
Autor(es): dc.contributorNational and Kapodistrian University of Athens (NKUA)-
Autor(es): dc.contributorSemmelweis University-
Autor(es): dc.contributorSir Ganga Ram Hospital-
Autor(es): dc.contributorNTNU - Norwegian University of Science and Technology-
Autor(es): dc.contributorSt Olavs University Hospital of Trondheim-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorUniversity Hospital of North Norway-
Autor(es): dc.contributorUiT the Arctic University of Norway-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad Autónoma de Nuevo León-
Autor(es): dc.contributorUniversity of Zagreb School of Medicine-
Autor(es): dc.creatorVan Straalen, Joeri W-
Autor(es): dc.creatorKrol, Roline M-
Autor(es): dc.creatorGiancane, Gabriella-
Autor(es): dc.creatorPanaviene, Violeta-
Autor(es): dc.creatorAilioaie, Laura Marinela-
Autor(es): dc.creatorDoležalová, Pavla-
Autor(es): dc.creatorCattalini, Marco-
Autor(es): dc.creatorSusic, Gordana-
Autor(es): dc.creatorSztajnbok, Flavio R-
Autor(es): dc.creatorMaritsi, Despoina-
Autor(es): dc.creatorConstantin, Tamas-
Autor(es): dc.creatorSawhney, Sujata-
Autor(es): dc.creatorRygg, Marite-
Autor(es): dc.creatorOliveira, Sheila Knupp-
Autor(es): dc.creatorNordal, Ellen Berit-
Autor(es): dc.creatorSaad-Magalhães, Claudia-
Autor(es): dc.creatorRubio-Perez, Nadina-
Autor(es): dc.creatorJelusic, Marija-
Autor(es): dc.creatorDe Roock, Sytze-
Autor(es): dc.creatorWulffraat, Nico M-
Autor(es): dc.creatorRuperto, Nicolino-
Autor(es): dc.creatorSwart, Joost F-
Data de aceite: dc.date.accessioned2025-08-21T15:29:32Z-
Data de disponibilização: dc.date.available2025-08-21T15:29:32Z-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2023-03-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/rheumatology/keab678-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/239852-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/239852-
Descrição: dc.descriptionObjective: To describe risk factors for IBD development in a cohort of children with JIA. Methods: JIA patients who developed IBD were identified from the international Pharmachild register. Characteristics were compared between IBD and non-IBD patients and predictors of IBD were determined using multivariable logistic regression analysis. Incidence rates of IBD events on different DMARDs were calculated, and differences between therapies were expressed as relative risks (RR). Results: Out of 8942 patients, 48 (0.54%) developed IBD. These were more often male (47.9% vs 32.0%) and HLA-B27 positive (38.2% vs 21.0%) and older at JIA onset (median 8.94 vs 5.33 years) than patients without IBD development. They also had more often a family history of autoimmune disease (42.6% vs 24.4%) and enthesitis-related arthritis (39.6% vs 10.8%). The strongest predictors of IBD on multivariable analysis were enthesitis-related arthritis [odds ratio (OR): 3.68, 95% CI: 1.41, 9.40] and a family history of autoimmune disease (OR: 2.27, 95% CI: 1.12, 4.54). Compared with methotrexate monotherapy, the incidence of IBD on etanercept monotherapy (RR: 7.69, 95% CI: 1.99, 29.74), etanercept with methotrexate (RR: 5.70, 95% CI: 1.42, 22.77) and infliximab (RR: 7.61, 95% CI: 1.27, 45.57) therapy was significantly higher. Incidence on adalimumab was not significantly different (RR: 1.45, 95% CI: 0.15, 13.89). Conclusion: IBD in JIA was associated with enthesitis-related arthritis and a family history of autoimmune disease. An increased IBD incidence was observed for etanercept therapy regardless of concomitant methotrexate use.-
Descrição: dc.descriptionEuropean Commission-
Descrição: dc.descriptionDepartment of Pediatric Immunology and Rheumatology Wilhelmina Children's Hospital-
Descrição: dc.descriptionClinica Pediatrica e Reumatologia IRCCS Istituto Giannina Gaslini-
Descrição: dc.descriptionDipartimento di Neuroscienze Riabilitazione Oftalmologia Genetica e Scienze Materno-Infantili (DiNOGMI) Università degli Studi di Genova-
Descrição: dc.descriptionChildren's Hospital Affiliate of Vilnius University Hospital Santaros Clinic-
Descrição: dc.descriptionClinic of Children's Diseases Vilnius University-
Descrição: dc.descriptionDepartment of Medical Physics Alexandru Ioan Cuza University of Iasi-
Descrição: dc.descriptionDepartment of Pediatrics and Inherited Metabolic Disorders 1st Faculty of Medicine General University Hospital Charles University in Prague-
Descrição: dc.descriptionUnita' di Immunologia e Reumatologia Pediatrica Clinica Pediatrica dell'Universita' di Brescia Spedali Civili-
Descrição: dc.descriptionDivision of Pediatric Rheumatology Institute of Rheumatology of Belgrade-
Descrição: dc.descriptionUnit of Rheumatology Adolescent Health Studies Center (NESA) Rio de Janeiro State University-
Descrição: dc.description2nd Department of Pediatrics Athens Medical School National and Kapodistrian University of Athens (NKUA)-
Descrição: dc.descriptionUnit of Pediatric Rheumatology-Immunology Second Department of Pediatrics Semmelweis University-
Descrição: dc.descriptionSir Ganga Ram Hospital Marg Centre for Child Health Sir Ganga Ram Hospital-
Descrição: dc.descriptionDepartment of Clinical and Molecular Medicine Faculty of Medicine and Health Sciences NTNU - Norwegian University of Science and Technology-
Descrição: dc.descriptionDepartment of Pediatrics St Olavs University Hospital of Trondheim-
Descrição: dc.descriptionInstituto de Puericultura e Pediatria Martagao Gesteira (IPPMG) Universidade Federal do Rio de Janeiro-
Descrição: dc.descriptionDepartment of Pediatrics University Hospital of North Norway-
Descrição: dc.descriptionDepartment of Clinical Medicine UiT the Arctic University of Norway-
Descrição: dc.descriptionPediatric Rheumatology Unit São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartamento de Pediatria Facultad de Medicina Hospital Universitario Dr. J. E. González Universidad Autónoma de Nuevo León, NL-
Descrição: dc.descriptionDepartment of Paediatrics University of Zagreb School of Medicine-
Descrição: dc.descriptionPediatric Rheumatology Unit São Paulo State University (UNESP)-
Descrição: dc.descriptionEuropean Commission: 260353-
Formato: dc.format2104-2112-
Idioma: dc.languageen-
Relação: dc.relationRheumatology (United Kingdom)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectenthesitis-related arthritis-
Palavras-chave: dc.subjectetanercept-
Palavras-chave: dc.subjectIBD-
Palavras-chave: dc.subjectJIA-
Título: dc.titleIncreased incidence of inflammatory bowel disease on etanercept in juvenile idiopathic arthritis regardless of concomitant methotrexate use-
Tipo de arquivo: dc.typelivro digital-
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