Avaliação de mediadores da resposta inflamatória na interface materno-fetal: Estudo in vitro de infecção bacteriana, isolada ou em combinação com Mycoplasma hominis, em células amnióticas epiteliais imortalizadas

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorSilva, Márcia Guimarães da-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCursino, Geovanna Cristofani-
Data de aceite: dc.date.accessioned2025-08-21T21:42:10Z-
Data de disponibilização: dc.date.available2025-08-21T21:42:10Z-
Data de envio: dc.date.issued2022-12-18-
Data de envio: dc.date.issued2022-12-18-
Data de envio: dc.date.issued2022-11-20-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/238299-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/238299-
Descrição: dc.descriptionTo evaluate the mediators of the inflammatory response, in an in vitro model, of immortalized epithelial amniotic cells (hFM-AECs) challenged by different bacterial species, alone and in combinations with Mycoplasma hominis, and the interference of this stimulus on the epithelial-mesenchymal transition. In vitro assay with hFM-AECs challenged with different species were performed in diferente moments. Supernatants were collected for quantification of IL-1β, IL-6, IL-8, IL-10, IL-13, GM-CSF, TNF-α, HBD-1, HBD-2 and HBD-3 by ELISA. For analyses of EMT, the cell shape index was applied. The data were subjected to a mixed effects model combined with parametric bootstrapping.One Way ANOVA and paired T-test were used for the EMT analysis. (a) Elevated levels of IL-6, IL-8, GM-CSF and HBD-1 were detected in relation to the reference when stimulated with Fusobacterium nucleatum, alone or in combination with M. hominis; (b) IL-13 levels were decreased in relation to the reference after stimulation with F. nucleatum, Bacteroides fragilis, Peptostreptococcus anaerobius and Streptococcus agalactiae alone and in combination with M. hominis; (c) Different isolates or combination with M. hominis stimulated EMT. F. nucleatum alone or in combination with M. hominis, have an important capacity to induce a characteristic inflammatory signature. Bacterial combinations stimulate EMT.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Formato: dc.formatapplication/pdf-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherUniversidade Estadual Paulista (UNESP)-
Direitos: dc.rightsinfo:eu-repo/semantics/openAccess-
Palavras-chave: dc.subjectIn vitro study-
Palavras-chave: dc.subjectImmortalized amnion epithelial cells (hFM-AECs)-
Palavras-chave: dc.subjectAdverse pregnancy outcome-
Palavras-chave: dc.subjectGenital mycoplasmas-
Palavras-chave: dc.subjectPolybacterial infection-
Palavras-chave: dc.subjectEpithelial-mesenchymal transition (EMT)-
Título: dc.titleAvaliação de mediadores da resposta inflamatória na interface materno-fetal: Estudo in vitro de infecção bacteriana, isolada ou em combinação com Mycoplasma hominis, em células amnióticas epiteliais imortalizadas-
Título: dc.titleEvaluation of inflammatory response mediators at maternal-fetal interface: In vitro study of bacterial infection, isolated or in combination with Mycoplasma hominis, in immortalized amniotic epithelial cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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