Integrated biosensors for monitoring microphysiological systems

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Autor(es): dc.contributorTerasaki Inst Biomed Innovat-
Autor(es): dc.contributorGuangzhou Med Univ-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMou, Lei-
Autor(es): dc.creatorMandal, Kalpana-
Autor(es): dc.creatorMecwan, Marvin Magan-
Autor(es): dc.creatorHernandez, Ana Lopez-
Autor(es): dc.creatorMaity, Surjendu-
Autor(es): dc.creatorSharma, Saurabh-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Autor(es): dc.creatorKawakita, Satoru-
Autor(es): dc.creatorJucaud, Vadim-
Autor(es): dc.creatorDokmeci, Mehmet Remzi-
Autor(es): dc.creatorKhademhosseini, Ali-
Data de aceite: dc.date.accessioned2025-08-21T16:51:38Z-
Data de disponibilização: dc.date.available2025-08-21T16:51:38Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-08-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d2lc00262k-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237963-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237963-
Descrição: dc.descriptionMicrophysiological systems (MPSs), also known as organ-on-a-chip models, aim to recapitulate the functional components of human tissues or organs in vitro. Over the last decade, with the advances in biomaterials, 3D bioprinting, and microfluidics, numerous MPSs have emerged with applications to study diseased and healthy tissue models. Various organs have been modeled using MPS technology, such as the heart, liver, lung, and blood-brain barrier. An important aspect of in vitro modeling is the accurate phenotypical and functional characterization of the modeled organ. However, most conventional characterization methods are invasive and destructive and do not allow continuous monitoring of the cells in culture. On the other hand, microfluidic biosensors enable in-line, real-time sensing of target molecules with an excellent limit of detection and in a non-invasive manner, thereby effectively overcoming the limitation of the traditional techniques. Consequently, microfluidic biosensors have been increasingly integrated into MPSs and used for in-line target detection. This review discusses the state-of-the-art microfluidic biosensors by providing specific examples, detailing their main advantages in monitoring MPSs, and highlighting current developments in this field. Finally, we describe the remaining challenges and potential future developments to advance the current state-of-the-art in integrated microfluidic biosensors.-
Descrição: dc.descriptionOffice of the Secretary of Defense through the Advanced Regenerative Manufacturing Institute (ARMI|BioFabUSA)-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionTerasaki Inst Biomed Innovat, 1018 Westwood Blvd, Los Angeles, CA 90024 USA-
Descrição: dc.descriptionGuangzhou Med Univ, Affiliated Hosp 3, Dept Clin Lab, 63 Duobao Rd, Guangzhou, Guangdong, Peoples R China-
Descrição: dc.descriptionSao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Bioproc & Biotechnol Engn, BR-14801902 Araraquara, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Bioproc & Biotechnol Engn, BR-14801902 Araraquara, SP, Brazil-
Descrição: dc.descriptionOffice of the Secretary of Defense through the Advanced Regenerative Manufacturing Institute (ARMI|BioFabUSA): W911NF-17-3-003-
Descrição: dc.descriptionNational Institutes of Health: R01AR074234-
Descrição: dc.descriptionNational Institutes of Health: R01GM126571-
Formato: dc.format16-
Idioma: dc.languageen-
Publicador: dc.publisherRoyal Soc Chemistry-
Relação: dc.relationLab On A Chip-
???dc.source???: dc.sourceWeb of Science-
Título: dc.titleIntegrated biosensors for monitoring microphysiological systems-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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