Reagentless Quantum-Rate-Based Electrochemical Signal of Graphene for Detecting SARS-CoV-2 Infection Using Nasal Swab Specimens

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorGarrote, Beatriz Lucas-
Autor(es): dc.creatorLopes, Lais C.-
Autor(es): dc.creatorPinzon, Edgar F.-
Autor(es): dc.creatorMendonca-Natividade, Flavia C.-
Autor(es): dc.creatorMartins, Ronaldo B.-
Autor(es): dc.creatorSantos, Adriano-
Autor(es): dc.creatorArruda, Eurico-
Autor(es): dc.creatorBueno, Paulo R.-
Data de aceite: dc.date.accessioned2025-08-21T15:10:29Z-
Data de disponibilização: dc.date.available2025-08-21T15:10:29Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acssensors.2c01016-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237962-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237962-
Descrição: dc.descriptionThe quantum-rate model predicts a rate k as a frequency for transporting electrons within molecular structures, which is governed by the ratio between the quantum of conductance G and capacitance Cq, such that k = G/Cq. This frequency, as measured in a single-layer graphene appropriately modified with suitable biological receptors, can be applied as a transducer signal that ranges sensitivities within the attomole for biosensing applications. Here, we applied this label-free and reagentless biosensing transducer signal methodology for the qualitative diagnosis of COVID-19 infections, where this assay methodology was shown to be similar to the gold-standard real-time polymerase chain reaction. The quantum-rate strategy for the diagnosis of COVID-19 was performed by combining the response of the interface for detecting the S and N proteins of SARS-CoV-2 virus as accessed from nasopharyngeal/oropharyngeal patient samples with 80% of sensitivity and 77% of specificity. As a label-free and reagentless biosensing platform, the methodology is decidedly useful for point-of-care and internet-of-things biological assaying technologies, not only because of its real-time ability to measure infections but also because of the capability for miniaturization inherent in reagentless electrochemical methods. This approach effectively permits the rapid development of biological assays for surveillance and control of endemics and pandemics.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSao Paulo State Univ, Inst Chem, Dept Engn Phys & Math, BR-14800060 Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Ribeirao Preto Med Sch, Dept Cell & Mol Biol & Pathogen Bioagents, BR-14049900 Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Inst Chem, Dept Engn Phys & Math, BR-14800060 Sao Paulo, Brazil-
Descrição: dc.descriptionFAPESP: 2017/24839-0-
Descrição: dc.description: 2018/26273-7-
Descrição: dc.description: 2018/23577-5-
Descrição: dc.description: 2018/24525-9-
Descrição: dc.description: 2020/12854-8-
Formato: dc.format9-
Idioma: dc.languageen-
Publicador: dc.publisherAmer Chemical Soc-
Relação: dc.relationAcs Sensors-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectQuantum rate-
Palavras-chave: dc.subjectElectrochemical capacitance-
Palavras-chave: dc.subjectSingle-layer graphene-
Palavras-chave: dc.subjectLabel-free-
Palavras-chave: dc.subjectReagentless-
Palavras-chave: dc.subjectAttomole sensitivity-
Palavras-chave: dc.subjectQualitative assay-
Palavras-chave: dc.subjectSARS-CoV-2-
Título: dc.titleReagentless Quantum-Rate-Based Electrochemical Signal of Graphene for Detecting SARS-CoV-2 Infection Using Nasal Swab Specimens-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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