CO2 exposure enhances Fos expression in hypothalamic neurons in rats during the light and dark phases of the diurnal cycle

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSilva, Eliandra N. da-
Autor(es): dc.creatorHorta-Junior, Jose de Anchieta C.-
Autor(es): dc.creatorGargaglioni, Luciane H.-
Autor(es): dc.creatorDias, Mirela B.-
Data de aceite: dc.date.accessioned2025-08-21T18:31:07Z-
Data de disponibilização: dc.date.available2025-08-21T18:31:07Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-09-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00429-022-02562-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237877-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237877-
Descrição: dc.descriptionOrexinergic (OX) neurons in the lateral hypothalamus (LH), perifornical area (PFA) and dorsomedial hypothalamus (DMH) play a role in the hypercapnic ventilatory response, presumably through direct inputs to central pattern generator sites and/or through interactions with other chemosensitive regions. OX neurons can produce and release orexins, excitatory neuropeptides involved in many functions, including physiological responses to changes in CO2/pH. Thus, in the present study, we tested the hypothesis that different nuclei (LH, PFA and DMH) where the orexinergic neurons are located, show distinct activation by CO2 during the light-dark cycle phases. For this purpose, we evaluated the Fos and OXA expression by immunohistochemistry to identify neurons that co-localize Fos + OXA in the LH, LPeF, MPeF and DMH in the light-inactive and dark-active phase in Wistar rats subjected to 3 h of normocapnia or hypercapnia (7% CO2). Quantitative analyses of immunoreactive neurons show that hypercapnia caused an increase in the number of neurons expressing Fos in the LH, LPeF, MPeF and DMH in the light and dark phases. In addition, the number of Fos + OXA neurons increased in the LPeF and DMH independently of the phases of the diurnal cycle; whereas in the MPeF, this increase was observed exclusively in the light phase. Thus, we suggest that OX neurons are selectively activated by hypercapnia throughout the diurnal cycle, reinforcing the differential role of nuclei in the hypothalamus during central chemosensitivity.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Fac Agr & Vet Sci, Dept Anim Morphol & Physiol, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Fac Agr & Vet Sci, Dept Anim Morphol & Physiol, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2013/04216-8-
Descrição: dc.descriptionFAPESP: 2019/17693-5-
Descrição: dc.descriptionFAPESP: 2016/131366-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCAPES: 88887.194785/2018-00-
Formato: dc.format13-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationBrain Structure & Function-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectCentral chemoreflex-
Palavras-chave: dc.subjectHypercapnia-
Palavras-chave: dc.subjectHypothalamus-
Palavras-chave: dc.subjectOrexins-
Título: dc.titleCO2 exposure enhances Fos expression in hypothalamic neurons in rats during the light and dark phases of the diurnal cycle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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