Nonpregnant and pregnant adult female rats affected by maternal diabetes environment

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorFed Univ Triangulo Mineiro UFTM-
Autor(es): dc.creatorPaula, Veronyca Goncalves-
Autor(es): dc.creatorSouza, Maysa Rocha de-
Autor(es): dc.creatorSinzato, Yuri Karen-
Autor(es): dc.creatorVillaverde, Ana Izabel Silva Balbin-
Autor(es): dc.creatorCorrente, Jose Eduardo-
Autor(es): dc.creatorVolpato, Gustavo Tadeu-
Autor(es): dc.creatorDamasceno, Debora Cristina-
Data de aceite: dc.date.accessioned2025-08-21T21:14:30Z-
Data de disponibilização: dc.date.available2025-08-21T21:14:30Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-09-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/19396368.2022.2115326-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237872-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237872-
Descrição: dc.descriptionMaternal diabetes-mediated fetal programming is widely discussed, however, it is important to define the extent to which intrauterine hyperglycemia interferes with the health of female pups, along with determining whether these changes can be perpetuated across generations. This study aimed to evaluate the effects of maternal diabetes on fetal programming and the repercussions on the metabolism of pregnant and nonpregnant female pups. Diabetes status was induced (diabetic group-D) using streptozotocin (a beta cell cytotoxic drug) on the fifth postnatal day of female rats, while controls received a citrate buffer (Control-C). In adulthood, the rats were mated to obtain their female pups. At 90 days of age, half of the female pups were mated (preg) and the other half continued virgin (Npreg). Furthermore, they were distributed into four groups: OC/Npreg and OC/preg-female pups from control mothers; OD/Npreg and OD/preg-female pups from diabetic mothers. At 115 days of life and/or 17 days of pregnancy, the oral glucose tolerance test (OGTT) was performed with blood collection for insulin measurement. At 120 days of life and/or 21 days of pregnancy, the rats were anesthetized and euthanized to determine their blood oxidative stress status. The OD/Npreg group showed glucose intolerance during OGTT (p < 0.0001), while the OD/preg group showed increased insulin secretion during OGTT (p < 0.0001) and insulin resistance (IR; p = 0.0027). An increase in homeostatic model assessment beta was shown in the pregnant groups, regardless of maternal diabetes (p < 0.0001). The OD/preg group presented increased thiobarbituric acid reactive substances (p < 0.0001) and -SH levels (p = 0.0005) and decreased superoxide dismutase activity (p = 0.0063). Additionally, small fetuses for gestational age (p < 0.0001) were found in these rats. In conclusion, exposure to maternal hyperglycemia compromises the glycemic metabolism of female pups before and during pregnancy and causes oxidative stress, IR, and impaired fetal growth during pregnancy.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Post Grad Course Tocogynecol, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Res Support Off, Botucatu, SP, Brazil-
Descrição: dc.descriptionFed Univ Mato Grosso UFMT, Inst Biol & Hlth Sci, Lab Syst Physiol & Reprod Toxicol, Barra Do Garcas, MG, Brazil-
Descrição: dc.descriptionFed Univ Triangulo Mineiro UFTM, Inst Biol & Nat Sci, Uberaba, MG, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Post Grad Course Tocogynecol, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Res Support Off, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2016/25207-5-
Formato: dc.format12-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Inc-
Relação: dc.relationSystems Biology In Reproductive Medicine-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectFetal programming-
Palavras-chave: dc.subjectHyperglycemia-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectInsulin resistance-
Palavras-chave: dc.subjectLow birth weight-
Título: dc.titleNonpregnant and pregnant adult female rats affected by maternal diabetes environment-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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