Perspective: Leveraging the Gut Microbiota to Predict Personalized Responses to Dietary, Prebiotic, and Probiotic Interventions

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Autor(es): dc.contributorInst Syst Biol-
Autor(es): dc.contributorUniv Washington-
Autor(es): dc.contributorUniv Geneva-
Autor(es): dc.contributorFred Hutchinson Canc Res Ctr-
Autor(es): dc.contributorCargill R&D Ctr Europe-
Autor(es): dc.contributorSensus BV Royal Cosun-
Autor(es): dc.contributorCatholic Univ Louvain-
Autor(es): dc.contributorUniv Surrey-
Autor(es): dc.contributorReckitt Mead Johnson Nutr Inst-
Autor(es): dc.contributorWageningen Univ & Res-
Autor(es): dc.contributorH&H Res-
Autor(es): dc.contributorIFF Hlth & Biosci-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorYakult Europe BV-
Autor(es): dc.contributorUniv Nottingham-
Autor(es): dc.contributorUniv Reading-
Autor(es): dc.contributorYili Innovat Ctr Europe-
Autor(es): dc.contributorBENEO Inst-
Autor(es): dc.contributorInt Life Sci Inst-
Autor(es): dc.creatorGibbons, Sean M.-
Autor(es): dc.creatorGurry, Thomas-
Autor(es): dc.creatorLampe, Johanna W.-
Autor(es): dc.creatorChakrabarti, Anirikh-
Autor(es): dc.creatorDam, Veerle-
Autor(es): dc.creatorEverard, Amandine-
Autor(es): dc.creatorGoas, Almudena-
Autor(es): dc.creatorGabriele, Gross-
Autor(es): dc.creatorKleerebez, Michiel-
Autor(es): dc.creatorLane, Jonathan-
Autor(es): dc.creatorMaukonen, Johanna-
Autor(es): dc.creatorPenna, Ana Lucia Barretto-
Autor(es): dc.creatorPot, Bruno-
Autor(es): dc.creatorValdes, Ana M.-
Autor(es): dc.creatorWalton, Gemma-
Autor(es): dc.creatorWeiss, Adrienne-
Autor(es): dc.creatorZanzer, Yoghatama Cindya-
Autor(es): dc.creatorVenlet, Naomi V.-
Autor(es): dc.creatorMiani, Michela-
Data de aceite: dc.date.accessioned2025-08-21T20:21:10Z-
Data de disponibilização: dc.date.available2025-08-21T20:21:10Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/advances/nmac075-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237840-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237840-
Descrição: dc.descriptionStatement of Significance: Humans often show variable responses to dietary, prebiotic, and probiotic interventions. Here, we provide an overview of some of the major computational and experimental tools being applied to critical questions of microbiota-mediated personalized nutrition and health. Humans often show variable responses to dietary, prebiotic, and probiotic interventions. Emerging evidence indicates that the gut microbiota is a key determinant for this population heterogeneity. Here, we provide an overview of some of the major computational and experimental tools being applied to critical questions of microbiota-mediated personalized nutrition and health. First, we discuss the latest advances in in silico modeling of the microbiota-nutrition-health axis, including the application of statistical, mechanistic, and hybrid artificial intelligence models. Second, we address high-throughput in vitro techniques for assessing interindividual heterogeneity, from ex vivo batch culturing of stool and continuous culturing in anaerobic bioreactors, to more sophisticated organ-on-a-chip models that integrate both host and microbial compartments. Third, we explore in vivo approaches for better understanding of personalized, microbiota-mediated responses to diet, prebiotics, and probiotics, from nonhuman animal models and human observational studies, to human feeding trials and crossover interventions. We highlight examples of existing, consumer-facing precision nutrition platforms that are currently leveraging the gut microbiota. Furthermore, we discuss how the integration of a broader set of the tools and techniques described in this piece can generate the data necessary to support a greater diversity of precision nutrition strategies. Finally, we present a vision of a precision nutrition and healthcare future, which leverages the gut microbiota to design effective, individual-specific interventions.-
Descrição: dc.descriptionInst Syst Biol, Seattle, WA 98109 USA-
Descrição: dc.descriptionUniv Washington, Dept Bioengn, Seattle, WA 98195 USA-
Descrição: dc.descriptionUniv Geneva, Sch Pharmaceut Sci, Pharmaceut Biochem Grp, Geneva, Switzerland-
Descrição: dc.descriptionUniv Geneva, Univ Lausanne, Inst Pharmaceut Sci Western Switzerland PSI WS, Geneva, Switzerland-
Descrição: dc.descriptionFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA-
Descrição: dc.descriptionCargill R&D Ctr Europe, Vilvoorde, Belgium-
Descrição: dc.descriptionSensus BV Royal Cosun, Roosendaal, Netherlands-
Descrição: dc.descriptionCatholic Univ Louvain, Metab & Nutr Res Grp, UCLouvain, Walloon Excellence Life Sci & BIOtechnol WELBIO,L, Brussels, Belgium-
Descrição: dc.descriptionUniv Surrey, Dept Food Nutr & Exercise Sci, Guildford, Surrey, England-
Descrição: dc.descriptionReckitt Mead Johnson Nutr Inst, Med & Sci Affairs, Nijmegen, Netherlands-
Descrição: dc.descriptionWageningen Univ & Res, Host Microbe Interact Grp, Wageningen, Netherlands-
Descrição: dc.descriptionH&H Res, Hlth & Happiness Grp, Cork, Ireland-
Descrição: dc.descriptionIFF Hlth & Biosci, Kantvik, Finland-
Descrição: dc.descriptionSao Paulo State Univ, Dept Food Engn & Technol, Sao Jose Do Rio Preto, Brazil-
Descrição: dc.descriptionYakult Europe BV, Almere, Netherlands-
Descrição: dc.descriptionUniv Nottingham, Nottingham NIHR Biomed Res Ctr, Sch Med, Nottingham, England-
Descrição: dc.descriptionUniv Reading, Food & Nutr Sci, Reading, Berks, England-
Descrição: dc.descriptionYili Innovat Ctr Europe, Wageningen, Netherlands-
Descrição: dc.descriptionBENEO Inst, Sudzucker Grp, Obrigheim Pfalz, Germany-
Descrição: dc.descriptionInt Life Sci Inst, European Branch, Brussels, Belgium-
Descrição: dc.descriptionSao Paulo State Univ, Dept Food Engn & Technol, Sao Jose Do Rio Preto, Brazil-
Formato: dc.format12-
Idioma: dc.languageen-
Publicador: dc.publisherOxford Univ Press-
Relação: dc.relationAdvances In Nutrition-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectPrebiotic-
Palavras-chave: dc.subjectProbiotic-
Palavras-chave: dc.subjectDiet-
Palavras-chave: dc.subjectMicrobiome-
Palavras-chave: dc.subjectMicrobiota-
Palavras-chave: dc.subjectPersonalized nutrition-
Palavras-chave: dc.subjectPersonalized healthcare-
Palavras-chave: dc.subjectPrecision nutrition-
Palavras-chave: dc.subjectPrecision healthcare-
Título: dc.titlePerspective: Leveraging the Gut Microbiota to Predict Personalized Responses to Dietary, Prebiotic, and Probiotic Interventions-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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