Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBarretos Board Hlth-
Autor(es): dc.contributorBiomeHub Res & Dev-
Autor(es): dc.creatorFerreira-Junior, Alexandre Soares-
Autor(es): dc.creatorBorgonovi, Tais Fernanda-
Autor(es): dc.creatorSalis, Larissa Vedovato Vilela de-
Autor(es): dc.creatorLeite, Aline Zazeri-
Autor(es): dc.creatorDantas, Amanda Soares-
Autor(es): dc.creatorSalis, Guilherme Vedovato Vilela de-
Autor(es): dc.creatorCruz, Giuliano Netto Flores-
Autor(es): dc.creatorOliveira, Luiz Felipe Valter de-
Autor(es): dc.creatorGomes, Eleni-
Autor(es): dc.creatorPenna, Ana Lucia Barretto-
Autor(es): dc.creatorDe Oliveira, Gislane Lelis Vilela-
Data de aceite: dc.date.accessioned2025-08-21T17:29:22Z-
Data de disponibilização: dc.date.available2025-08-21T17:29:22Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijerph191610189-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237832-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237832-
Descrição: dc.descriptionThe intestinal microbiota plays an important role in the immune response against viral infections, modulating both innate and adaptive immune responses. The cytokine storm is associated with COVID-19 severity, and the patient's immune status is influenced by the intestinal microbiota in a gut-lung bidirectional interaction. In this study, we evaluate the intestinal microbiota of Brazilian patients in different post-COVID-19 periods, and correlate this with clinical data and the antibiotic therapy used during the acute phase. DNA extracted from stool samples was sequenced and total anti-SARS-CoV-2 antibodies and C-reactive protein were quantified. Compared with controls, there were significant differences in the microbiota diversity in post-COVID-19 patients, suggesting an intestinal dysbiosis even several months after acute disease resolution. Additionally, we detected some genera possibly associated with the post-COVID-19 dysbiosis, including Desulfovibrio, Haemophillus, Dialister, and Prevotella, in addition to decreased beneficial microbes, associated with antibiotic-induced dysbiosis, such as Bifidobacterium and Akkermansia. Therefore, our hypothesis is that dysbiosis and the indiscriminate use of antibiotics during the pandemic may be associated with post-COVID-19 clinical manifestations. In our study, 39% (n = 58) of patients reported symptoms, including fatigue, dyspnea, myalgia, alopecia, anxiety, memory loss, and depression. These data suggest that microbiota modulation may represent a target for recovery from acute COVID-19 and a therapeutic approach for post-COVID-19 sequelae.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInst Biosci Humanities & Exact Sci IBILCE, Microbiol Program, BR-15054000 Sao Jose Do Rio Preto, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Food Engn & Technol Dept, BR-15054000 Sao Jose Do Rio Preto, Brazil-
Descrição: dc.descriptionBarretos Board Hlth, Emergency Care Unit, BR-14780900 Barretos, Brazil-
Descrição: dc.descriptionBiomeHub Res & Dev, BR-88054700 Florianopolis, SC, Brazil-
Descrição: dc.descriptionInst Biosci Humanities & Exact Sci IBILCE, Microbiol Program, BR-15054000 Sao Jose Do Rio Preto, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Food Engn & Technol Dept, BR-15054000 Sao Jose Do Rio Preto, Brazil-
Descrição: dc.descriptionCAPES: 88887.310463/2018-00-
Descrição: dc.descriptionCAPES: 88887.572 564/2020-00-
Descrição: dc.descriptionFAPESP: 2022/0000-0-
Descrição: dc.descriptionCNPq: 313190/2021-6-
Descrição: dc.descriptionCNPq: 313909/2020-2-
Formato: dc.format15-
Idioma: dc.languageen-
Publicador: dc.publisherMdpi-
Relação: dc.relationInternational Journal Of Environmental Research And Public Health-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectPost-COVID-19-
Palavras-chave: dc.subjectIntestinal microbiota-
Palavras-chave: dc.subjectDysbiosis-
Palavras-chave: dc.subjectAntibiotics-
Palavras-chave: dc.subjectSequelae-
Título: dc.titleDetection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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