Update on Melasma-Part I: Pathogenesis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.creatorEsposito, Ana Claudia C.-
Autor(es): dc.creatorCassiano, Daniel P.-
Autor(es): dc.creatorSilva, Carolina N. da-
Autor(es): dc.creatorLima, Paula B.-
Autor(es): dc.creatorDias, Joana A. F.-
Autor(es): dc.creatorHassun, Karime-
Autor(es): dc.creatorBagatin, Edileia-
Autor(es): dc.creatorMiot, Luciane D. B.-
Autor(es): dc.creatorMiot, Helio Amante-
Data de aceite: dc.date.accessioned2025-08-21T22:03:52Z-
Data de disponibilização: dc.date.available2025-08-21T22:03:52Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-07-29-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s13555-022-00779-x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237796-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237796-
Descrição: dc.descriptionMelasma is a multifactorial dyschromia that results from exposure to external factors (such as solar radiation) and hormonal factors (such as sex hormones and pregnancy), as well as skin inflammation (such as contact dermatitis and esthetic procedures), in genetically predisposed individuals. Beyond hyperfunctional melanocytes, skin with melasma exhibits a series of structural and functional alterations in the epidermis, basement membrane, and upper dermis that interact to elicit and sustain a focal hypermelanogenic phenotype. Evolution in the knowledge of the genetic basis of melasma and the cutaneous response to solar radiation, as well as the roles of endocrine factors, antioxidant system, endothelium proliferation, fibroblast senescence, mast cell degranulation, autophagy deficits of the melanocyte, and the paracrine regulation of melanogenesis, will lead to the development of new treatments and preventive strategies. This review presents current knowledge on these aspects of the pathogenesis of melasma and discusses the effects of specific treatments and future research on these issues.-
Descrição: dc.descriptionUNESP, Dept Dermatol & Radioterapia, FMB Unesp, SN Campus Rubiao Jr, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Fed Sao Paulo, Dept Dermatol, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUNESP, Dept Dermatol & Radioterapia, FMB Unesp, SN Campus Rubiao Jr, BR-18618000 Botucatu, SP, Brazil-
Formato: dc.format1967-1988-
Idioma: dc.languageen-
Publicador: dc.publisherAdis Int Ltd-
Relação: dc.relationDermatology And Therapy-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectMelasma-
Palavras-chave: dc.subjectPathogenesis-
Palavras-chave: dc.subjectMelanocytes-
Palavras-chave: dc.subjectMelanin-
Palavras-chave: dc.subjectPhotoaging-
Palavras-chave: dc.subjectUV radiation-
Título: dc.titleUpdate on Melasma-Part I: Pathogenesis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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