Effects of a maternal high-fat diet on adipose tissue in murine offspring: A systematic review and meta-analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorFac Med Botucatu-
Autor(es): dc.contributorUNIPEX-
Autor(es): dc.creatorSaullo, Carolina-
Autor(es): dc.creatorCruz, Larissa Lopes da-
Autor(es): dc.creatorDamasceno, Debora Cristina-
Autor(es): dc.creatorVolpato, Gustavo Tadeu-
Autor(es): dc.creatorSinzato, Yuri Karen-
Autor(es): dc.creatorKarki, Barshana-
Autor(es): dc.creatorGallego, Franciane Quintanilha-
Autor(es): dc.creatorVesentini, Giovana-
Data de aceite: dc.date.accessioned2025-08-21T21:32:54Z-
Data de disponibilização: dc.date.available2025-08-21T21:32:54Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.biochi.2022.06.009-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237789-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237789-
Descrição: dc.descriptionThe aim of this systematic review and meta-analysis was to analyze the influence of a maternal and/or offspring high-fat diet (HFD) on the morphology of the offspring adipocytes and amount of food and energy consumption. The search was conducted through Pubmed, EMBASE, and Web of Science data-bases up to October 31st, 2021. The outcomes were extracted and pooled as a standardized mean dif-ference with random effect models. 5,004 articles were found in the databases. Of these, only 31 were selected for this systematic review and 21 were included in the meta-analysis. A large discrepancy in the percentage of fat composing the HFD (from 14% to 62% fat content) was observed. Considering the in-crease of adipose tissue by hyperplasia (cell number increase) and hypertrophy (cell size increase) in HFD models, the meta-analysis showed that excessive consumption of a maternal HFD influences the development of visceral white adipose tissue in offspring, related to adipocyte hypertrophy, regardless of their HFD or control diet consumption. Upon following a long-term HFD, hyperplasia was confirmed in the offspring. When analyzing the secondary outcome in terms of the amount of food and energy consumed, there was an increase of caloric intake in the offspring fed with HFD whose mothers consumed HFD. Furthermore, the adipocyte hypertrophy in different regions of the adipose tissue is related to the sex of the pups. Thus, the adipose tissue obesity phenotypes in offspring are programmed by maternal consumption of a high-fat diet, independent of postnatal diet.(c) 2022 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Postgrad Course Tocogynecol, Botucatu, SP, Brazil-
Descrição: dc.descriptionFed Univ Mato Grosso UFMT, Inst Biol & Hlth Sci, Lab Syst Physiol & Reprod Toxicol, Barra Garcas, Mato Grosso, Brazil-
Descrição: dc.descriptionFac Med Botucatu, Lab Pesquisa Expt Ginecol & Obstet, BR-18610879 Botucatu, Brazil-
Descrição: dc.descriptionUNIPEX, Fac Med Botucatu, BR-18610879 Botucatu, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Postgrad Course Tocogynecol, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2016/25207-5-
Formato: dc.format18-32-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationBiochimie-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectHyperlipidic diet-
Palavras-chave: dc.subjectRats-
Palavras-chave: dc.subjectPups-
Palavras-chave: dc.subjectAdipose tissue-
Palavras-chave: dc.subjectSystematic review-
Título: dc.titleEffects of a maternal high-fat diet on adipose tissue in murine offspring: A systematic review and meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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