Multigenerational Effects of an Environmentally Relevant Phthalate Mixture on Reproductive Parameters and Ovarian miRNA Expression in Female Rats

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Autor(es): dc.contributorUniv Illinois-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGonsioroski, Andressa-
Autor(es): dc.creatorAquino, Ariana M.-
Autor(es): dc.creatorAlonso-Costa, Luiz G.-
Autor(es): dc.creatorBarbisan, Luis F.-
Autor(es): dc.creatorScarano, Wellerson R.-
Autor(es): dc.creatorFlaws, Jodi A.-
Data de aceite: dc.date.accessioned2025-08-21T17:52:46Z-
Data de disponibilização: dc.date.available2025-08-21T17:52:46Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-06-28-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/toxsci/kfac066-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237775-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237775-
Descrição: dc.descriptionPhthalates are endocrine-disrupting chemicals used in many consumer products. Our laboratory previously developed an environmentally relevant phthalate mixture consisting of 6 phthalates and found that it disrupted female fertility in mice. However, it was unknown if maternal exposure to the mixture affects reproductive parameters and ovarian post-transcription in the F1 and F2 generation of female rats. Thus, we tested the hypothesis that maternal exposure to the phthalate mixture affects folliculogenesis, steroidogenesis, and ovarian microRNA (miRNA) in the F1 and F2 generations of female rats. Pregnant female rats were divided into 4 groups and orally dosed daily from gestational day 10 to postnatal day 21 with corn oil (control group), 20 mu g/kg/day, 200 mu g/kg/day, or 200 mg/kg/day of the phthalate mixture. Maternal exposure to the phthalate mixture impaired folliculogenesis in the F1 and F2 generations of female rats and affected steroidogenesis in the F1 generation of female rats compared to control. Further, the phthalate mixture altered ovarian expression of some genes related to the cell cycle and steroidogenesis compared to control in the F1 and F2 generations of female rats. The mixture also increased ovarian expression of rno-mir-184 that is involved with the oocyte maturation process. Collectively, our data show that maternal exposure to the phthalate mixture affects folliculogenesis and steroidogenesis in the F1 and F2 generations of female rats and alters ovarian miRNA expression in the F1 generation of female rats.-
Descrição: dc.descriptionNational Institutes of Health (NIH)-
Descrição: dc.descriptionEnvironmental Toxicology Fellowship-
Descrição: dc.descriptionLemann Center for Brazilian Studies-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniv Illinois, Dept Comparat Biosci, Urbana, IL 61802 USA-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, BR-18618689 Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, BR-18618689 Botucatu, SP, Brazil-
Descrição: dc.descriptionNational Institutes of Health (NIH): R01 ES 028661-
Descrição: dc.descriptionNational Institutes of Health (NIH): NIH R01 ES 032163-
Descrição: dc.descriptionFAPESP: 2017/08306-2-
Descrição: dc.descriptionFAPESP: 2018/50002-3-
Descrição: dc.descriptionCNPq: 303418/2019-2-
Descrição: dc.descriptionCNPq: 303751/2018-5-
Formato: dc.format91-106-
Idioma: dc.languageen-
Publicador: dc.publisherOxford Univ Press-
Relação: dc.relationToxicological Sciences-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectPhthalates-
Palavras-chave: dc.subjectOvary-
Palavras-chave: dc.subjectSteroidogenesis-
Palavras-chave: dc.subjectEndocrine-disrupting chemicals-
Palavras-chave: dc.subjectMiRNA-
Título: dc.titleMultigenerational Effects of an Environmentally Relevant Phthalate Mixture on Reproductive Parameters and Ovarian miRNA Expression in Female Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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