Serjania marginata Casar. Hydroalcoholic Extract Reduced Cytokine and Inflammatory Parameters in Experimental Models of Inflammation and Infection in Mice

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFed Univ Grande Dourados-
Autor(es): dc.contributorUnigran Capital Univ Ctr-
Autor(es): dc.contributorAnhanguera Uniderp Univ-
Autor(es): dc.contributorUniversidade Estadual de Mato Grosso do Sul (UEMS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLeitao, Maicon Matos-
Autor(es): dc.creatorRadai, Joyce Alencar Santos-
Autor(es): dc.creatorMacorini, Luis Fernando Benitez-
Autor(es): dc.creatorFraga, Thiago Leite-
Autor(es): dc.creatorHeredia-Vieira, Silvia Cristina-
Autor(es): dc.creatorCardoso, Claudia Andrea Lima-
Autor(es): dc.creatorArena, Arielle Cristina-
Autor(es): dc.creatorKassuya, Candida Aparecida Leite-
Data de aceite: dc.date.accessioned2025-08-21T23:38:34Z-
Data de disponibilização: dc.date.available2025-08-21T23:38:34Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.5530/pres.14.2.18-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237772-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237772-
Descrição: dc.descriptionObjectives: This study investigated the antimycobacterial, anti-inflammatory and antihyperalgesic effects of hydroalcoholic extract from leaves of S. marginata (EESM) in in vitro and in vivo models. Methods and Results: EESM (0.98-1000 mu g/ml) was evaluated in in vitro against Mycobacterium tuberculosis, M. bovis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus epidermidis. The EESM oral administration (p.o.) (30, 100 and 300 mg/kg) and dexamethasone subcutaneous injection (s.c.) (1 mg/kg) were tested against the carrageenan-induced inflammatory paw edema and pleurisy in Swiss mice. The EESM (30 and 100 mg/kg, p.o.) and dexamethasone (1 mg/kg, s.c.) were tested against the CFA-induced paw inflammation and M. bovis (bacillus Calmette-Guerin - BCG)-induced pleurisy in C57bL6 mice. The minimum inhibitory concentration (MIC) of EESM in the presence of M. tuberculosis was 62.4 mu g/ml. The values of MIC of EESM in the presence S. epidermidis, K. pneumoniae were 1000 mu g/mL while EESM did not interfere against P. aeruginosa growth. EESM significantly inhibited paw edema/mechanical hyperalgesia in carrageenan induced paw inflammation and leukocytes migration/proteins exudation in carrageenan-induced pleurisy model. In the BCGinduced pleurisy model, the daily treatment for 7 days, with EESM inhibited the levels of IL-1 beta in blood and in pleural exudate. The EESM did not alter the mycobacterial growth in the cell culture from pleural lavage, spleen and liver samples collected from BCG-treated animals. The EESM significantly inhibited the persistent edema and mechanical hyperalgesia induced by CFA. Conclusion: This study confirms the EESM anti-inflammatory property and showed that EESM has high potency in inducing inhibition of mycobaterial growth and low potency or no effects in relation to other microorganisms.-
Descrição: dc.descriptionFed Univ Grande Dourados, Sch Hlth Sci, Dourados, MS, Brazil-
Descrição: dc.descriptionUnigran Capital Univ Ctr, Sch Hlth Sci, Campo Grande, MS, Brazil-
Descrição: dc.descriptionAnhanguera Uniderp Univ, Ctr Hlth Sci, Campo Grande, MS, Brazil-
Descrição: dc.descriptionMato Grosso do Sul State Univ, Ctr Studies Nat Resources, Dourados, MS, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Inst Biosci Botucatu, Dept Morphol, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Inst Biosci Botucatu, Dept Morphol, Botucatu, SP, Brazil-
Formato: dc.format127-134-
Idioma: dc.languageen-
Publicador: dc.publisherPhcog Net-
Relação: dc.relationPharmacognosy Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Palavras-chave: dc.subjectBacillus Calmette-Guerin (BCG)-
Palavras-chave: dc.subjectCipo-timbo-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectTuberculosis-
Título: dc.titleSerjania marginata Casar. Hydroalcoholic Extract Reduced Cytokine and Inflammatory Parameters in Experimental Models of Inflammation and Infection in Mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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