Untargeted Metabolomics Sheds Light on the Diversity of Major Classes of Secondary Metabolites in the Malpighiaceae Botanical Family

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniv Calif-
Autor(es): dc.contributorRoyal Bot Gardens Kew-
Autor(es): dc.contributorFeira St ana State Univ UEFS-
Autor(es): dc.contributorFed Inst Educ-
Autor(es): dc.contributorMax Planck Inst Mol Plant Physiol-
Autor(es): dc.contributorFed Univ Alfenas UNIFAL-
Autor(es): dc.creatorMannochio-Russo, Helena-
Autor(es): dc.creatorAlmeida, Rafael F. de-
Autor(es): dc.creatorNunes, Wilhan D. G.-
Autor(es): dc.creatorBueno, Paula C. P.-
Autor(es): dc.creatorCaraballo-Rodriguez, Andres M.-
Autor(es): dc.creatorBauermeister, Anelize-
Autor(es): dc.creatorDorrestein, Pieter C.-
Autor(es): dc.creatorBolzani, Vanderlan S.-
Data de aceite: dc.date.accessioned2025-08-21T19:29:01Z-
Data de disponibilização: dc.date.available2025-08-21T19:29:01Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-04-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fpls.2022.854842-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237731-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237731-
Descrição: dc.descriptionNatural products produced by plants are one of the most investigated natural sources, which substantially contributed to the development of the natural products field. Even though these compounds are widely explored, the literature still lacks comprehensive investigations aiming to explore the evolution of secondary metabolites produced by plants, especially if classical methodologies are employed. The development of sensitive hyphenated techniques and computational tools for data processing has enabled the study of large datasets, being valuable assets for chemosystematic studies. Here, we describe a strategy for chemotaxonomic investigations using the Malpighiaceae botanical family as a model. Our workflow was based on MS/MS untargeted metabolomics, spectral searches, and recently described in silico classification tools, which were mapped into the latest molecular phylogeny accepted for this family. The metabolomic analysis revealed that different ionization modes and extraction protocols significantly impacted the chemical profiles, influencing the chemotaxonomic results. Spectral searches within public databases revealed several clades or genera-specific molecular families, being potential chemical markers for these taxa, while the in silico classification tools were able to expand the Malpighiaceae chemical space. The classes putatively annotated were used for ancestral character reconstructions, which recovered several classes of metabolites as homoplasies (i.e., non-exclusive) or synapomorphies (i.e., exclusive) for all sampled clades and genera. Our workflow combines several approaches to perform a comprehensive evolutionary chemical study. We expect it to be used on further chemotaxonomic investigations to expand chemical knowledge and reveal biological insights for compounds classes in different biological groups.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionBrazilian Fulbright Commission-
Descrição: dc.descriptionGordon and Betty Moore Foundation-
Descrição: dc.descriptionU.S. National Institutes of Health for the Center-
Descrição: dc.descriptionFederal Award-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Chem, Dept Biochem & Organ Chem, NuBBE, Araraquara, Brazil-
Descrição: dc.descriptionUniv Calif, Collaborat Mass Spectrometry Innovat Ctr, Skaggs Sch Pharm & Pharmaceut Sci, San Diego, CA USA-
Descrição: dc.descriptionRoyal Bot Gardens Kew, Sci, Ecosyst Stewardship, Divers & Livelihoods, Richmond, England-
Descrição: dc.descriptionFeira St ana State Univ UEFS, Dept Biol Sci, Lamol Lab, Feira De Santana, Brazil-
Descrição: dc.descriptionFed Inst Educ, Sci & Technol Rondonia, IFRO, Ji Parana, Brazil-
Descrição: dc.descriptionMax Planck Inst Mol Plant Physiol, Potsdam, Germany-
Descrição: dc.descriptionFed Univ Alfenas UNIFAL, Inst Chem, Alfenas, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Chem, Dept Biochem & Organ Chem, NuBBE, Araraquara, Brazil-
Descrição: dc.descriptionFAPESP: 2013/07600-3-
Descrição: dc.descriptionCNPq: 2014/465637-0-
Descrição: dc.descriptionCNPq: 142014/2018-4-
Descrição: dc.descriptionFAPESP: 2017/19702-6-
Descrição: dc.descriptionFAPESP: 2019/08477-7-
Descrição: dc.descriptionFAPESP: 2018/24865-4-
Descrição: dc.descriptionGordon and Betty Moore Foundation: GBMF7622-
Descrição: dc.descriptionU.S. National Institutes of Health for the Center: P41 GM103484-
Descrição: dc.descriptionU.S. National Institutes of Health for the Center: R01 GM107550-
Descrição: dc.descriptionFederal Award: DE-SC0021340-
Descrição: dc.descriptionFederal Award: 1070261-436503-
Descrição: dc.descriptionFAPESP: 2014/50926-0-
Formato: dc.format19-
Idioma: dc.languageen-
Publicador: dc.publisherFrontiers Media Sa-
Relação: dc.relationFrontiers In Plant Science-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectChemotaxonomy-
Palavras-chave: dc.subjectMass spectrometry-
Palavras-chave: dc.subjectMetabolite annotation-
Palavras-chave: dc.subjectMetabolomics-
Palavras-chave: dc.subjectEvolution-
Palavras-chave: dc.subjectAncestral character reconstruction-
Palavras-chave: dc.subjectSystematics-
Palavras-chave: dc.subjectMalpighiales-
Título: dc.titleUntargeted Metabolomics Sheds Light on the Diversity of Major Classes of Secondary Metabolites in the Malpighiaceae Botanical Family-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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