Vaginal Microbiome Components as Correlates of Cervical Human Papillomavirus Infection

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniv Fed Parana-
Autor(es): dc.contributorMcGill Univ-
Autor(es): dc.contributorUniv Maryland-
Autor(es): dc.contributorUniversidade Federal da Paraíba (UFPB)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorState Univ Para-
Autor(es): dc.creatorMorales, Julia Andrade Pessoa-
Autor(es): dc.creatorMarconi, Camila-
Autor(es): dc.creatorEl-Zein, Mariam-
Autor(es): dc.creatorRavel, Jacques-
Autor(es): dc.creatorPinto, Gabriel Victor da Silva-
Autor(es): dc.creatorSilveira, Rosana-
Autor(es): dc.creatorLima, Moises Diogo de-
Autor(es): dc.creatorCarvalho, Newton Sergio de-
Autor(es): dc.creatorAlves, Rosane Ribeiro Figueiredo-
Autor(es): dc.creatorParada, Cristina Maria Garcia de Lima-
Autor(es): dc.creatorMorais Leite, Sandra Helena-
Autor(es): dc.creatorVilla, Luisa L.-
Autor(es): dc.creatorFranco, Eduardo L.-
Autor(es): dc.creatorSilva, Marcia Guimaraes da-
Data de aceite: dc.date.accessioned2025-08-21T20:16:49Z-
Data de disponibilização: dc.date.available2025-08-21T20:16:49Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-01-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/infdis/jiab547-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237724-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237724-
Descrição: dc.descriptionBackground Interplay between vaginal microbiome and human papillomavirus (HPV) remains unclear, partly due to heterogeneity of microbiota. Methods We used data from 546 women enrolled in a cross-sectional study in 5 Brazil. We genotyped vaginal samples for HPV and sequenced V3-V4 region of 16S rRNA gene for vaginal microbiome analysis. We used stepwise logistic regression to construct 2 linear scores to predict high-risk HPV (hrHPV) positivity: one based exclusively on presence of individual bacterial taxa (microbiome-based [MB] score) and the other exclusively on participants' sociodemographic, behavioral, and clinical (SBC) characteristics. MB score combined coefficients of 30 (of 116) species. SBC score retained 6 of 25 candidate variables. We constructed receiver operating characteristic curves for scores as hrHPV correlates and compared areas under the curve (AUC) and 95% confidence intervals (CI). Results Overall, prevalence of hrHPV was 15.8%, and 26.2% had a Lactobacillus-depleted microbiome. AUCs were 0.8022 (95% CI, .7517-.8527) for MB score and 0.7027 (95% CI, .6419-.7636) for SBC score (P = .0163). Conclusions The proposed MB score is strongly correlated with hrHPV positivity-exceeding the predictive value of behavioral variables-suggesting its potential as an indicator of infection and possible value for clinical risk stratification. This cross-sectional study demonstrated a strong correlation between vaginal microbiome components and cervical high-risk HPV positivity.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCancer Research Society-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Fed Parana, Dept Basic Pathol, Curitiba, Parana, Brazil-
Descrição: dc.descriptionMcGill Univ, Div Canc Epidemiol, Montreal, PQ, Canada-
Descrição: dc.descriptionUniv Maryland, Sch Med, Inst Genom Sci, Baltimore, MD 21201 USA-
Descrição: dc.descriptionFed Univ Paraiba UFPB, Dept Gynecol & Obstet, Joao Pessoa, Paraiba, Brazil-
Descrição: dc.descriptionFed Univ Goias UFG, Dept Gynecol & Obstet, Goiania, Go, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Nursing, Botucatu, SP, Brazil-
Descrição: dc.descriptionState Univ Para, Dept Gynecol & Obstet, Belem, Para, Brazil-
Descrição: dc.descriptionSao Paulo State Univ USP, Ctr Translat Invest Oncol, Med Sch, Canc Inst Sao Paulo State, Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Nursing, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ USP, Ctr Translat Invest Oncol, Med Sch, Canc Inst Sao Paulo State, Sao Paulo, Brazil-
Descrição: dc.descriptionFAPESP: 2012/01278-0-
Descrição: dc.descriptionFAPESP: 2012/16800-3-
Descrição: dc.descriptionFAPESP: 2012/10403-2-
Descrição: dc.descriptionFAPESP: 2018/18469-9-
Formato: dc.format14-
Idioma: dc.languageen-
Publicador: dc.publisherOxford Univ Press Inc-
Relação: dc.relationJournal Of Infectious Diseases-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectVaginal microbiome-
Palavras-chave: dc.subjectHPV infection-
Palavras-chave: dc.subjecthigh-risk HPV-
Palavras-chave: dc.subject16S RNA sequencing-
Título: dc.titleVaginal Microbiome Components as Correlates of Cervical Human Papillomavirus Infection-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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