Testicular alterations in cryptorchid/orchiopexic rats chronically exposed to acrylamide or di-butyl-phthalate

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAllergisa Pesquisa Dermato Cosmet-
Autor(es): dc.contributorUniv Louisville-
Autor(es): dc.contributorCtr Univ Sudoeste Paulista UniFSP-
Autor(es): dc.contributorSyngenta Crop Protect-
Autor(es): dc.contributorUniv Nebraska Med Ctr-
Autor(es): dc.creatorLima, Thania R. R.-
Autor(es): dc.creatorSouza, Nathalia P.-
Autor(es): dc.creatorCardoso, Ana P. Ferragut-
Autor(es): dc.creatorGomide, Ligia M. M.-
Autor(es): dc.creatorPontes, Merielen G. Nascimento e-
Autor(es): dc.creatorMiot, Helio A.-
Autor(es): dc.creatorArnold, Lora L.-
Autor(es): dc.creatorCohen, Samuel M.-
Autor(es): dc.creatorCamargo, Joao Lauro V. de-
Data de aceite: dc.date.accessioned2025-08-21T23:29:25Z-
Data de disponibilização: dc.date.available2025-08-21T23:29:25Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1293/tox.2021-0045-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237721-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237721-
Descrição: dc.descriptionExposure of Sprague-Dawley (SD) rats to acrylamide (AA) or di-butyl-phthalate (DBP) from the 12th gestational day to the 16th postnatal week (PNW) has been shown to reduce the effectiveness of orchiopexy in recovering the testicular alterations associated with experimental cryptorchidism established at weaning. Herein, we provide information about the long-term effects of AA or DBP on the testes of cryptorchid/orchiopexic rats. Male offspring exposed in utero to 10 mg/kg/day AA or 500 mg/kg/day DBP underwent bilateral surgical cryptorchidism at the 3rd PNW and orchiopexy at the 6th week, with continuous exposure to the chemicals through diet until the 58th week. Regardless of the test chemical, there were severe qualitative/quantitative alterations in the seminiferous tubules and increased numbers of Leydig cells. There was an increase and decrease in the number of tubules with c-Kit- and placental alkaline phosphatase-labeled germ cells, respectively, as compared to those in the control group, suggesting an imbalance between apoptosis and cell proliferation processes. The histological scores of the testicular lesions at the end of this one-year study were higher than those in the previous 16-week study, indicating that exposure of rats to the toxicants AA or DBP enhanced the testicular alterations induced by the chemicals beginning at the intra-uterine life, and impaired the effectiveness of orchiopexy in restoring the testes to normal morphology. Although the present experimental protocol does not completely replicate the natural human undescended testes, our findings may contribute to understanding the alterations occurring in cryptorchid/orchiopexic testes potentially exposed to exogenous chemicals for extended periods. (DOI: 10.1293/tox.2021-0045; J Toxicol Pathol 2022; 35: 159-170)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionCenter for Evaluation of Environmental Impact on Human Health (TOXICAM), Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, Ctr Evaluat Environm Impact Human Hlth TOXICAM, BR-18618687 Botucatu, SP, Brazil-
Descrição: dc.descriptionAllergisa Pesquisa Dermato Cosmet, BR-13083897 Campinas, SP, Brazil-
Descrição: dc.descriptionUniv Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40202 USA-
Descrição: dc.descriptionCtr Univ Sudoeste Paulista UniFSP, BR-18213145 Itapetininga, SP, Brazil-
Descrição: dc.descriptionSyngenta Crop Protect, BR-04730000 Sao Paulo, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Dermatol & Radiotherapy, BR-18618687 Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68105 USA-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, Ctr Evaluat Environm Impact Human Hlth TOXICAM, BR-18618687 Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Dermatol & Radiotherapy, BR-18618687 Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2012/09873-4-
Formato: dc.format159-170-
Idioma: dc.languageen-
Publicador: dc.publisherJapanese Soc Toxicologic Pathology-
Relação: dc.relationJournal Of Toxicologic Pathology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectRat surgical cryptorchidism-
Palavras-chave: dc.subjectOrchiopexy-
Palavras-chave: dc.subjectChronic toxicity-
Palavras-chave: dc.subjectTesticular germ cells-
Palavras-chave: dc.subjectDi-butyl-phthalate-
Palavras-chave: dc.subjectAcrylamide-
Título: dc.titleTesticular alterations in cryptorchid/orchiopexic rats chronically exposed to acrylamide or di-butyl-phthalate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.