Metabolic profiling and cytotoxic activity of methanol extracts from Chamaecrista duckeana (P. BEZERRA & A. FERN.) H. S. IRWIN & BARNEBY (LEGUMINOSAE, CAESALPINIOIDEAE)

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Autor(es): dc.contributorUniv Fed Ceara-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLima, Daniele Rodrigues de-
Autor(es): dc.creatorFranca, Maria Gleiziane de Araujo-
Autor(es): dc.creatorOliveira, Fatima de Cassia Evangelista de-
Autor(es): dc.creatorPessoa, Claudia do O.-
Autor(es): dc.creatorCavalheiro, Alberto Jose-
Autor(es): dc.creatorSilva, Maria Goretti de Vasconcelos-
Data de aceite: dc.date.accessioned2025-08-21T17:24:54Z-
Data de disponibilização: dc.date.available2025-08-21T17:24:54Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-04-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.21577/0100-4042.20170885-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237710-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237710-
Descrição: dc.descriptionThe genus Chamaecrista comprises more than 330 species, with only a few studies on their chemical composition and biologic activities. In this study, the phytochemical profile of leaf, stems, and fruits extracts of the C. duckeana were examined by UPLC-ESI-HRMS analysis to determine possibly bioactive constituents. The antioxidant activity was carried out through in vitro assay, by the sequestration of the free radical DPPH. To evaluate the cytotoxic activity of the extracts, an MTT assay was used and the IC50 was determined against HL60 and RAJI cell lines. The metabolic profiles of the botanical parts are dominated by flavonoid class, highlighting isoflavonoids such as daidzin and ononin. All these compounds are reported for the first time in C. duckeana. The extracts presented antioxidant potential, and the activity of the stems extract was higher than the standard butylated hydroxytoluene. In the cytotoxic assay, only HL60 line (leukemia) had growth inhibition over 80%. The stems presented more expressive cytotoxicity with IC50 of 137.3 (104.6-180.1) and 106.8 (96.52-118.3) mu mol. L-1 for HL60 and RAJI, respectively. In conclusion, the present work provides an in-depth knowledge about the chemical profile of C. duckeana, a species rich in bioactive secondary metabolites with cytotoxic activity.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Fed Ceara, Dept Quim Anal & Fisicoquim, BR-60455970 Fortaleza, Ceara, Brazil-
Descrição: dc.descriptionUniv Fed Ceara, Dept Fisiol & Farmacol, BR-60431970 Fortaleza, Ceara, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil-
Descrição: dc.descriptionCNPq: 465637/2014-0/FAPESP 2014/50926-0-
Descrição: dc.descriptionFAPESP: 2013/07600-3-
Formato: dc.format4-
Idioma: dc.languageen-
Publicador: dc.publisherSoc Brasileira Quimica-
Relação: dc.relationQuimica Nova-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectChamaecrista duckeana-
Palavras-chave: dc.subjectUPLC-ESI-HRMS-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectIsoflavonoids-
Título: dc.titleMetabolic profiling and cytotoxic activity of methanol extracts from Chamaecrista duckeana (P. BEZERRA & A. FERN.) H. S. IRWIN & BARNEBY (LEGUMINOSAE, CAESALPINIOIDEAE)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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