Histomorphometric analysis of the endometrium in an ectopic model of endometriosis in mice

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorQueens Univ-
Autor(es): dc.creatorSilva, Felipe Rosendo da-
Autor(es): dc.creatorThimoteo, Daniel Soares-
Autor(es): dc.creatorCarbonel, Adriana Ferraz-
Autor(es): dc.creatorPortugal Fuchs, Luiz Fernando-
Autor(es): dc.creatorSasso, Gisela Rodrigues da Silva-
Autor(es): dc.creatorSimoes, Ricardo dos Santos-
Autor(es): dc.creatorInvitti, Adriana-
Autor(es): dc.creatorVieira, Renata Ramos-
Autor(es): dc.creatorFerreira, Luiz Philipe de Souza-
Autor(es): dc.creatorSilva, Rafael Andre da-
Autor(es): dc.creatorLima, Patricia Daniele Azevedo-
Autor(es): dc.creatorSoares Junior, Jose Maria-
Autor(es): dc.creatorSimoes, Manuel de Jesus-
Autor(es): dc.creatorAntonio Bertoncini, Clelia Rejane-
Data de aceite: dc.date.accessioned2025-08-21T19:18:27Z-
Data de disponibilização: dc.date.available2025-08-21T19:18:27Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-08-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/09513590.2022.2119218-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237687-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237687-
Descrição: dc.descriptionObjective: Evaluate histomorphometry of ectopic and eutopic endometrial tissues in receptor mice. Method: Eighteen female Balb/c were divided into 3 groups, 6 animals each: GI Control, no procedure; GII - Sham, animals that had the same procedures as GIII without receiving the ectopic endometrial implant. Instead, they received saline solution; GIII - endometriosis model, animals had surgical intervention with an ectopic endometrial implant. GI and GIII mice were treated with 17 beta-estradiol, 100 mu g/kg each. All animals were euthanized to collect uterine horns, which were fixed in 4% paraformaldehyde, embedded in paraffin, stained with Hematoxilin and Eosin and submitted to histomorphometric analyzes. Data underwent one-way ANOVA followed by Tukey's test. Results: Local tissue growth, showing important lesions and adhesions, as well as dark cysts were noticed. In GIII group, there was an increase in number of blood vessels and glands (GIII >= GI and GIII p > .001). Thickening of the GIII endometrial epithelial was also evident (GIII >= GI and GIII. p > .001). We also noticed an increase in the number of eosinophils (GIII (GIII >= GI and GIII. p > .001). Conclusion: Easy to perform model, capable of reproducing morphological endometriosis characteristics. From our findings, there was an increase of endometrial thickness as well as an increase in the eosinophils population.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFed Univ Sao Paulo EPM UNIFESP, Paulista Sch Med, Dept Gynecol, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Fed Sao Paulo EPM UNIFESP, Paulista Sch Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo FMUSP, Med Fac, Dept Obstet & Gynecol, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ IBILCE, Inst Biosci Letters & Exact Sci, UNESP, Biosci Grad Program, Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionQueens Univ, Queens Cardiopulm Unit QCPU, Kingston, ON, Canada-
Descrição: dc.descriptionSao Paulo State Univ IBILCE, Inst Biosci Letters & Exact Sci, UNESP, Biosci Grad Program, Sao Jose Do Rio Preto, SP, Brazil-
Formato: dc.format5-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Ltd-
Relação: dc.relationGynecological Endocrinology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectMouse-
Palavras-chave: dc.subjectHistomorphometry-
Palavras-chave: dc.subjectFemale infertility-
Título: dc.titleHistomorphometric analysis of the endometrium in an ectopic model of endometriosis in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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