Triphenylphosphine gold(I) derivatives promote antiviral effects against the Chikungunya virus

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorMax Planck Inst Polymer Res-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAires, Rochanna L.-
Autor(es): dc.creatorSantos, Igor A.-
Autor(es): dc.creatorFontes, Josielle-
Autor(es): dc.creatorBergamini, Fernando R. G.-
Autor(es): dc.creatorJardim, Ana Carolina G.-
Autor(es): dc.creatorAbbehausen, Camilla-
Data de aceite: dc.date.accessioned2025-08-21T19:45:59Z-
Data de disponibilização: dc.date.available2025-08-21T19:45:59Z-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-11-29-
Data de envio: dc.date.issued2022-08-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/mtomcs/mfac056-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/237661-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/237661-
Descrição: dc.descriptionHerein a systematic series of four [AuLL'](n+) n = 0, +1 complexes, where L = 1,3-bis(mesityl)imidazole-2-ylidene (IMes), or triphenylphosphine (PPh3), and L' = chloride, or 4-dimethylaminopyridine (DMAP), had their in vitro antiviral activity assessed against Chikungunya virus (CHIKV). The PPh3 derivatives inhibited viral replication by 99%, whereas the IMes derivatives about 50%. The lipophilicity of the PPh3 derivatives is higher than the IMes-bearing compounds, which can be related to their more prominent antiviral activities. The dissociation of DMAP is faster than chloride in solution for both IMes and PPh3 derivatives; however, it does not significantly affect their in vitro activities, showing a higher dependence on the nature of L rather than L' towards their antiviral effects. All complexes bind to N-acetyl-L-cysteine, with the Ph3P-bearing complexes coordinating at a faster rate to this amino acid. The binding constants to bovine serum albumin are in the order of 10(4), slightly higher for the DMAP complexes in both PPh3 and IMes derivatives. Mechanistic investigations of the PPh3 complexes showed a ubiquitous protective effect of the compounds in the pretreatment, early stages, and post-entry assays. The most significant inhibition was observed in post-entry activity, in which the complexes blocked viral replication in 99%, followed by up to 95% inhibition of the early stages of infection. Pretreatment assays showed a 92% and 80% replication decrease for the chloride and DMAP derivatives, respectively. dsRNA binding assays showed a significant interaction of the compounds with dsRNA, an essential biomolecule to viral replication.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Estadual Campinas, Inst Chem, UNICAMP, BR-13083871 Campinas, SP, Brazil-
Descrição: dc.descriptionUniv Fed Uberlandia, Inst Biomed Sci, BR-38405302 Uberlandia, MG, Brazil-
Descrição: dc.descriptionUniv Fed Uberlandia, Inst Chem, Lab Synth Bioinspired Mol, BR-38408100 Uberlandia, MG, Brazil-
Descrição: dc.descriptionMax Planck Inst Polymer Res, Ackermannweg 10, D-55128 Mainz, Germany-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci Humanities & Exact Sci Ibilce, UNESP, Campus Sao Jose do Rio Preto, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci Humanities & Exact Sci Ibilce, UNESP, Campus Sao Jose do Rio Preto, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionCNPq: 142495/2020-4-
Descrição: dc.descriptionCAPES: 88881.506794/2020-01-
Descrição: dc.descriptionFAPEMIG: APQ-01613-21-
Descrição: dc.descriptionCNPq: 200829/2020-3-
Descrição: dc.descriptionFAPEMIG: APQ-03385-18-
Descrição: dc.descriptionFAPESP: 2019/16904-2-
Descrição: dc.descriptionCNPq: 406444/2018-8-
Descrição: dc.descriptionCAPES: 88887372957/2019-00-
Descrição: dc.descriptionCAPES: 88887373256/2019-00-
Formato: dc.format12-
Idioma: dc.languageen-
Publicador: dc.publisherOxford Univ Press-
Relação: dc.relationMetallomics-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectChikungunya-
Palavras-chave: dc.subjectGold-
Palavras-chave: dc.subjectMetallodrugs-
Palavras-chave: dc.subjectAntivirals-
Título: dc.titleTriphenylphosphine gold(I) derivatives promote antiviral effects against the Chikungunya virus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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