Melanin-concentrating hormone regulates the hypercapnic chemoreflex by acting in the lateral hypothalamic area

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDias, Mirela B.-
Autor(es): dc.creatorGargaglioni, Luciane H-
Autor(es): dc.creatorPatrone, Luis G.A.-
Autor(es): dc.creatorRodrigues, Laísa TC-
Data de aceite: dc.date.accessioned2025-08-21T21:23:47Z-
Data de disponibilização: dc.date.available2025-08-21T21:23:47Z-
Data de envio: dc.date.issued2022-06-20-
Data de envio: dc.date.issued2022-06-20-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/235199-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/235199-
Descrição: dc.descriptionMelanin-concentrating hormone (MCH) is a hypothalamic neuropeptide involved in a broad range of homeostatic functions including regulation of the hypercapnic chemoreflex. We evaluated whether MCH modulates the hypercapnic ventilatory response by acting in the lateral hypothalamic area (LHA) and/or in the locus coeruleus (LC). Here, we measured pulmonary ventilation ( E), body temperature, EEG and EMG of unanesthetized male Wistar rats before and after microinjection of MCH [0.4 mM] into the LHA and LC, or the MCH1-R antagonist (SNAP-94847 [63 mM]), into the LHA, in room air and in 7% CO2 during wakefulness and sleep, in the dark and light periods. MCH intra-LHA caused a decreased CO2 ventilatory response during wakefulness and sleep, while SNAP-94847 intra-LHA increased this response, during wakefulness in the light period. In the LC, MCH or the MCH1-R antagonist caused no change in the hypercapnic ventilatory response. Our results suggest that MCH, in the LHA, exerts an inhibitory modulation of the hypercapnic ventilatory response during the light-inactive period in rats.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nivel Superior (CAPES)-
Descrição: dc.descriptionFAPESP:2019/17693-5-
Descrição: dc.descriptionFAPESP: 2018/01781-0-
Descrição: dc.descriptionCAPES: 88887.194785/2018-00-
Formato: dc.formatpdf-
Formato: dc.formatapplication/pdf-
Formato: dc.formatapplication/pdf-
Formato: dc.formatapplication/pdf-
Formato: dc.formatapplication/pdf-
Formato: dc.formatapplication/pdf-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsinfo:eu-repo/semantics/openAccess-
Palavras-chave: dc.subjectBreathing-
Palavras-chave: dc.subjectChemoreceptors-
Palavras-chave: dc.subjectHypothalamus-
Palavras-chave: dc.subjectBreathing-
Título: dc.titleMelanin-concentrating hormone regulates the hypercapnic chemoreflex by acting in the lateral hypothalamic area-
Tipo de arquivo: dc.typeplanilha-
Aparece nas coleções:Repositório Institucional - Unesp

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