Folic acid-modified curcumin-loaded liposomes for breast cancer therapy

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLuiz, Marcela Tavares-
Autor(es): dc.creatorDutra, Jessyca Aparecida Paes-
Autor(es): dc.creatorRibeiro, Taís de Cássia-
Autor(es): dc.creatorCarvalho, Gabriela Corrêa-
Autor(es): dc.creatorSábio, Rafael Miguel-
Autor(es): dc.creatorMarchetti, Juliana Maldonado-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T21:23:40Z-
Data de disponibilização: dc.date.available2025-08-21T21:23:40Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-07-20-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.colsurfa.2022.128935-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234360-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234360-
Descrição: dc.descriptionBreast cancer is the commonest cancer among women, with more than 2 million cases per year and a lethality rate of 17.7%. The treatment of breast cancer still being a challenge due to the high heterogeneity of tumor cells. In this scenario, the development of targeted nanosystems for drug delivery has been investigated. Thus, the aim of this study was the development and characterization of folic acid-modified curcumin-loaded liposomes (LIP-CCM-FA) for the treatment of breast cancer. For this purpose, LIP-CCM-FA and unmodified liposomes (LIP-CCM) were developed and characterized in vitro using MCF-7 cells culture in two-dimensional (2D) and three-dimensional (3D) models. LIP-CCM and LIP-CCM-FA showed low particles size (~ 138 nm), narrow polydispersity indexes (~ 0.140), negative zeta potential (~ −13 mV), and high drug encapsulation efficiency (> 73%). Furthermore, LIP-CCM-FA showed a significantly greater cytotoxicity effect when compared with free curcumin and LIP-CCM using 2D and 3D cell culture models. In addition, in vitro cellular uptake assays using 2D and 3D models indicated higher cellular internalization and spheroid penetration of LIP-CCM-FA when compared with free curcumin and LIP-CCM, suggesting the potential of folic acid modification for improving drug internalization in breast cancer cells through its recognition by folate receptors overexpressed. In summary, this novel nanosystem demonstrated a greater in vitro antitumoral effect due to its ability to permeate tissues and be specifically recognized by folate receptors.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSchool of Pharmaceutical Science of Ribeirao Preto University of Sao Paulo (USP)-
Descrição: dc.descriptionSchool of Pharmaceutical Science of Sao Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Science of Sao Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationColloids and Surfaces A: Physicochemical and Engineering Aspects-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectActive targeting-
Palavras-chave: dc.subjectDrug delivery systems-
Palavras-chave: dc.subjectFolate-
Palavras-chave: dc.subjectLiposomal-
Palavras-chave: dc.subjectNanoparticles-
Palavras-chave: dc.subjectNanotechnology-
Título: dc.titleFolic acid-modified curcumin-loaded liposomes for breast cancer therapy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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