Involvement of V1-type vasopressin receptors on NaCl intake by hyperosmotic rats treated with muscimol in the lateral parabrachial nucleus

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCallera, João C.-
Autor(es): dc.creatorDe Luca, Laurival A.-
Autor(es): dc.creatorMenani, José V.-
Data de aceite: dc.date.accessioned2025-08-21T21:39:45Z-
Data de disponibilização: dc.date.available2025-08-21T21:39:45Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2022.136601-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234328-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234328-
Descrição: dc.descriptionGABAA receptor activation with agonist muscimol in the lateral parabrachial nucleus (LPBN) induces 0.3 M NaCl intake. In the present study, we investigated water and 0.3 M NaCl intake in male adult rats treated with losartan (angiotensin AT1 receptor antagonist) or MeT-AVP (V1-type vasopressin receptor antagonist) combined with muscimol or methysergide (5-HT2 antagonist) into the LPBN in rats treated with intragastric 2 M NaCl. After 2 M NaCl load and bilateral injections of muscimol (0.5 nmol/0.2 µL) into the LPBN, rats ingested water and 0.3 M NaCl. The pre-treatment of the LPBN with MeT-AVP (1 nmol/0.2 µL) but not losartan (50 µg/0.2 µL) in muscimol treated rats reduced 0.3 M NaCl intake. The pre-treatment of the LPBN with MeT-AVP did not modify the increased 0.3 M NaCl intake in rats treated with methysergide (4 µg/0.2 µL), suggesting that the effect of MeT-AVP was not due to non-specific inhibition of ingestive behavior. The results suggest that endogenous vasopressin in the LPBN facilitates the effects of GABAergic activation driving cell-dehydrated male rats to ingest 0.3 M NaCl.-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry Sao Paulo State University (UNESP), Rodovia Marechal Rondom, Km 527, 16018-805, SP-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry UNESP, SP-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry Sao Paulo State University (UNESP), Rodovia Marechal Rondom, Km 527, 16018-805, SP-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationNeuroscience Letters-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDehydration-
Palavras-chave: dc.subjectGABAA receptor-
Palavras-chave: dc.subjectOsmoreceptor-
Palavras-chave: dc.subjectSodium appetite-
Palavras-chave: dc.subjectThirst-
Título: dc.titleInvolvement of V1-type vasopressin receptors on NaCl intake by hyperosmotic rats treated with muscimol in the lateral parabrachial nucleus-
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Aparece nas coleções:Repositório Institucional - Unesp

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