Small genetic variation affecting mRNA isoforms associated with marbling and meat color in beef cattle

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorNational Council for Scientific and Technological Development (CNPq)-
Autor(es): dc.contributorUniversity of Guelph-
Autor(es): dc.creatorMuniz, Maria Malane Magalhães-
Autor(es): dc.creatorFonseca, Larissa Fernanda Simielli-
Autor(es): dc.creatordos Santos Silva, Danielly Beraldo-
Autor(es): dc.creatorMagalhães, Ana Fabrícia Braga-
Autor(es): dc.creatorFerro, Jesus Aparecido-
Autor(es): dc.creatorChardulo, Luiz Artur Loyola-
Autor(es): dc.creatorBaldi, Fernando-
Autor(es): dc.creatorCánovas, Angela-
Autor(es): dc.creatorde Albuquerque, Lucia Galvão-
Data de aceite: dc.date.accessioned2025-08-21T16:35:43Z-
Data de disponibilização: dc.date.available2025-08-21T16:35:43Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10142-022-00844-w-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234297-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234297-
Descrição: dc.descriptionThe aim of this study was to identify mRNA isoforms and small genetic variants that may be affecting marbling and beef color in Nellore cattle. Longissimus thoracis muscle samples from 20 bulls with different phenotypes (out of 80 bulls set) for marbling (moderate (n = 10) and low (n = 10) groups) and beef color (desirable (n = 10) and undesirable (n = 9) group) traits were used to perform transcriptomic analysis using RNA sequencing. Fourteen and 15 mRNA isoforms were detected as differentially expressed (DE) (P-value ≤ 0.001) between divergent groups for marbling and meat color traits, respectively. Some of those DE mRNA isoforms have shown sites of splicing modified by small structural variants as single nucleotide variant (SNV), insertion, and/or deletion. Enrichment analysis identified metabolic pathways, such as O2/CO2 exchange in erythrocytes, tyrosine biosynthesis, and phenylalanine degradation. The results obtained suggest potential key regulatory genes associated with these economically important traits for the beef industry and for the consumer.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSchool of Agricultural and Veterinarian Sciences São Paulo State University (Unesp), SP-
Descrição: dc.descriptionNational Council for Scientific and Technological Development (CNPq)-
Descrição: dc.descriptionCollege of Veterinary and Animal Science São Paulo State University (Unesp), SP-
Descrição: dc.descriptionCentre for Genetic Improvement of Livestock Department of Animal Biosciences University of Guelph-
Descrição: dc.descriptionSchool of Agricultural and Veterinarian Sciences São Paulo State University (Unesp), SP-
Descrição: dc.descriptionCollege of Veterinary and Animal Science São Paulo State University (Unesp), SP-
Idioma: dc.languageen-
Relação: dc.relationFunctional and Integrative Genomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDeletion-
Palavras-chave: dc.subjectGenetic variants-
Palavras-chave: dc.subjectInsertion-
Palavras-chave: dc.subjectNellore breed-
Palavras-chave: dc.subjectRNA sequencing-
Palavras-chave: dc.subjectSingle nucleotide variant (SNV)-
Título: dc.titleSmall genetic variation affecting mRNA isoforms associated with marbling and meat color in beef cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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