Screen-Printed Electrodes on Tyvek Substrate as Low-Cost Device to Applications in Alzheimer's Disease Detection

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Autor(es): dc.contributorInstituto Tecnológico de Aeronaútica-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Do Vale Do Paraíba-
Autor(es): dc.contributorInstituto de Aeronáutica e Espaço-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPalley, Bianca Fortes-
Autor(es): dc.creatorArtur, Julio Cesar-
Autor(es): dc.creatorDe Arruda, Milena Nakagawa-
Autor(es): dc.creatorDe Souza, Gustavo Freitas-
Autor(es): dc.creatorGraves, David Alexandro-
Autor(es): dc.creatorBovolato, Ana Lívia De Carvalho-
Autor(es): dc.creatorDeffune, Elenice-
Autor(es): dc.creatorSchelp, Arthur Oscar-
Autor(es): dc.creatorGonçalves, Emerson Sarmento-
Autor(es): dc.creatorDe Moraes, Marli Leite-
Data de aceite: dc.date.accessioned2025-08-21T18:39:12Z-
Data de disponibilização: dc.date.available2025-08-21T18:39:12Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1149/1945-7111/ac584f-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234291-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234291-
Descrição: dc.descriptionAlzheimer's disease (AD) is a progressive neurodegenerative disease characterized by impairment of cognitive functions and memory deterioration, which requires an early diagnosis for effective treatment. The use of immunosensors to detect Alzheimer s disease biomarkers stand out as a quick and cheap alternative for early detection of the disease. The development of Screen-Printed Electrodes (SPEs) meets a growing demand in the market for applications such as signal transducers in biosensor devices. In this work was development a method for fabrication of low cost SPE for application in the detection of Alzheimer s disease through autoantibodies. It was produced microelectrodes on polyvinyl chloride (PVC), polyvinylidene fluoride (PVDF) and high-density polyethylene (HDPE) manufactured by DuPont Tyvek®substrates. SPEs produced on Tyvek®substrates have shown promising results for low-cost, disposable and flexible sensors. The carbon paste showed excellent adhesion to Tyvek®substrate and the electrodes produced showed an electrochemical performance comparable to commercial electrodes, besides reproducible. The detection results showed that it is possible to detect anti-Aβ40 autoantibodies in real samples of serum and cerebrospinal fluid using the electrode modified with two bilayers of (PEI/(DDPG + Aβ40)) since the capacitance increased more in positive sample with the presence of autoantibody than in negative samples.-
Descrição: dc.descriptionInstituto Tecnológico de Aeronaútica, SP-
Descrição: dc.descriptionUniversidade Federal de São Paulo Instituto de Ciência e Tecnologia, SP-
Descrição: dc.descriptionUniversidade Do Vale Do Paraíba, SP-
Descrição: dc.descriptionInstituto de Aeronáutica e Espaço, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Hemocentro de Botucatu, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Hemocentro de Botucatu, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of the Electrochemical Society-
???dc.source???: dc.sourceScopus-
Título: dc.titleScreen-Printed Electrodes on Tyvek Substrate as Low-Cost Device to Applications in Alzheimer's Disease Detection-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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