Cylindrospermopsin Disrupts Estrous Cycle and Increases Spermatogenesis in Mice

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Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Moraes, Adriana Carvalho Natal-
Autor(es): dc.creatorCaires, Fernanda Oliveira-
Autor(es): dc.creatorImperio, Guinever Eustaquio-
Autor(es): dc.creatorNóbrega, Rafael Henrique-
Autor(es): dc.creatorOrtiga-Carvalho, Tania Maria-
Autor(es): dc.creatorde Magalhães, Valéria Freitas-
Data de aceite: dc.date.accessioned2025-08-21T22:18:23Z-
Data de disponibilização: dc.date.available2025-08-21T22:18:23Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s43032-022-00907-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234230-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234230-
Descrição: dc.descriptionCylindrospermopsin (CYN) is a water-soluble cyanotoxin that has been linked to several cases of poisoning in the world. In vitro studies have shown that CYN acts as an endocrine disruptor by inhibiting progesterone synthesis in primary cell cultures of women, showing estrogenic activity. However, in vivo assessment of CYN in the female and male reproductive systems remains unknown. We thus aimed to evaluate the in vivo effects of CYN in both the female and male reproductive systems of mice. A single intraperitoneal exposure to 64 µg of CYN/kg body weight was performed in females. Estrous cycle was evaluated daily by vaginal cytology, and serum progesterone and estradiol levels were measured after 50 days. We showed an impairment in the estrous cycle as well as a decrease in circulating plasma progesterone levels. In males, weekly intraperitoneal doses of 20 μg of CYN/kg body weight were given and groups were killed after one, two, or four doses. CYN increased the testosterone levels in the groups that received one or two doses of CYN. Additionally, CYN induced a transient increase in spermatozoa in males after four doses. Our results highlight that CYN interferes with both male and female reproductive systems and may lead to infertility. As far as we know, this is the first report showing the impacts of CYN on the mammalian reproductive system, suggesting a threat from this cyanotoxin to human and environmental health.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)-
Descrição: dc.descriptionLaboratory of Ecophysiology and Toxicology of Cyanobacteria Institute of Biophysics Carlos Chagas Filho UFRJ, RJ-
Descrição: dc.descriptionLaboratory of Translational Endocrinology Institute of Biophysics Carlos Chagas Filho UFRJ, RJ-
Descrição: dc.descriptionReproductive and Molecular Biology Group Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionReproductive and Molecular Biology Group Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationReproductive Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCyanotoxins-
Palavras-chave: dc.subjectEndocrine disruptor-
Palavras-chave: dc.subjectIn vivo-
Palavras-chave: dc.subjectReproductive toxicology-
Título: dc.titleCylindrospermopsin Disrupts Estrous Cycle and Increases Spermatogenesis in Mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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