Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Grande Dourados - Dourados-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorOswaldo Cruz Foundation-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso Do Sul-
Autor(es): dc.contributorYale University School of Public Health-
Autor(es): dc.creatorMoreira, Flora Martinez Figueira-
Autor(es): dc.creatorRadai, Joyce Alencar Santos-
Autor(es): dc.creatorde Souza, Vanessa Vilamaior-
Autor(es): dc.creatorBerno, Claudia Rodrigues-
Autor(es): dc.creatorde Araújo, Flavio Henrique Souza-
Autor(es): dc.creatorAndrade-Silva, Magaiver-
Autor(es): dc.creatorOliveira, Rodrigo Juliano-
Autor(es): dc.creatorArena, Arielle Cristina-
Autor(es): dc.creatorHenriques, Maria das Graças Müller de Oliveira-
Autor(es): dc.creatorKassuya, Candida Aparecida Leite-
Autor(es): dc.creatorCroda, Julio-
Data de aceite: dc.date.accessioned2025-08-21T17:04:47Z-
Data de disponibilização: dc.date.available2025-08-21T17:04:47Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.phyplu.2021.100117-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234218-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234218-
Descrição: dc.descriptionBackground: Studies have reported that compounds similar to flavone present antimicrobial and anti-inflammatory properties; however these effects are poorly described in the context of mycobacterium infection. Purpose: This study investigated the efficacy of 2-phenylchromone (Flavone) on mycobacteria viability and inflammatory response induced by Mycobacterium bovis, as well as its toxicological potential in in vitro and in vivo models. Methods: In vitro antimycobacterial activity was performed using the resazurin microtiter assay method. In order to investigate the anti-inflammatory action, C57Bl/6 mice were pretreated orally with 2-phenylchromone (1–100 mg/kg) 1 h before the pleurisy induction. The leukocyte migration and cytokine production were evaluated. Acute oral toxicity test, genotoxicity evaluations and splenic phagocytosis assay were also evaluated. Results: The minimum inhibitory concentration of 2-phenylchromone in the presence of the Mycobacterium tuberculosis strain was 28.90 µg/mL. In the BCG-induced pleurisy model, the oral treatment with 2-phenylchromone (1, 10, or 100 mg/kg) caused a significant reduction in the tumor necrosis factor (TNF) levels in the pleural exudate, as well as in the total and differential leukocyte counts. The oral treatment with 2-phenylchromone also did not present acute toxicity or genotoxicity in comet assay and micronucleus tests. However, 2-phenylchromone induced an increase of 1.48-times in splenic phagocytosis in the animals. Conclusion: Our results showed that 2-phenylchromone did not induced toxicity signs and is effective against Mycobacterium viability and reduced the inflammatory response elicited by mycobacteria.-
Descrição: dc.descriptionFaculty of Health Sciences Federal University of Grande Dourados - Dourados, Mato Grosso do Sul State-
Descrição: dc.descriptionFederal University of Mato Grosso do Sul (UFMS), MS-
Descrição: dc.descriptionOswaldo Cruz Foundation, RJ-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionSchool of Medicine Federal University of Mato Grosso Do Sul, MS-
Descrição: dc.descriptionDepartment of Epidemiology of Microbial Diseases Yale University School of Public Health-
Descrição: dc.descriptionOswaldo Cruz Foundation, MS-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPhytomedicine Plus-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute toxicity-
Palavras-chave: dc.subjectComet assay-
Palavras-chave: dc.subjectMicronucleus test-
Palavras-chave: dc.subjectMinimum inhibitory concentration-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Palavras-chave: dc.subjectPleurisy-
Título: dc.titleToxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.