Cellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of ABC-
Autor(es): dc.contributorUniversity of Sorocaba-
Autor(es): dc.creatorRogerio, Carolina B.-
Autor(es): dc.creatorCarvalho Abrantes, Daniele-
Autor(es): dc.creatorDe Oliveira, Jhones L.-
Autor(es): dc.creatorRibeiro De Araújo, Daniele-
Autor(es): dc.creatorGermano Da Costa, Tais-
Autor(es): dc.creatorDe Lima, Renata-
Autor(es): dc.creatorFernandes Fraceto, Leonardo-
Data de aceite: dc.date.accessioned2025-08-21T16:43:11Z-
Data de disponibilização: dc.date.available2025-08-21T16:43:11Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-03-21-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acsabm.1c01286-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234176-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234176-
Descrição: dc.descriptionThe most important arboviruses are those that cause dengue, yellow fever, chikungunya, and Zika, for which the main vector is the Aedes aegypti mosquito. The use of repellents is an important way to combat mosquito-borne pathogens. In this work, a safe method of protection employing a repellent was developed based on a slow release system composed of zein nanoparticles containing the active agents icaridin and geraniol incorporated in a cellulose gel matrix. Analyses were performed to characterize the nanoparticles and the gel formulation. The nanoparticles containing the repellents presented a hydrodynamic diameter of 229 ± 9 nm, polydispersity index of 0.38 ± 0.10, and zeta potential of +29.4 ± 0.8 mV. The efficiencies of encapsulation in the zein nanoparticles exceeded 85% for icaridin and 98% for geraniol. Rheological characterization of the gels containing nanoparticles and repellents showed that the viscoelastic characteristic of hydroxypropylmethylcellulose gel was preserved. Release tests demonstrated that the use of nanoparticles in combination with the gel matrix led to improved performance of the formulations. Atomic force microscopy analyses enabled visualization of the gel network containing the nanoparticles. Cytotoxicity assays using 3T3 and HaCaT cell cultures showed low toxicity profiles for the active agents and the nanoparticles. The results demonstrated the potential of these repellent systems to provide prolonged protection while decreasing toxicity.-
Descrição: dc.descriptionInstitute of Science and Technology São Paulo State University (UNESP), Avenida Três de Março 511, Alto da Boa Vista, São Paulo-
Descrição: dc.descriptionFaculty of Agronomy and Veterinary Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFederal University of ABC, São Paulo-
Descrição: dc.descriptionLaboratory of Bioactivity Assessment and Toxicology of Nanomaterials University of Sorocaba, São Paulo-
Descrição: dc.descriptionInstitute of Science and Technology São Paulo State University (UNESP), Avenida Três de Março 511, Alto da Boa Vista, São Paulo-
Descrição: dc.descriptionFaculty of Agronomy and Veterinary Sciences São Paulo State University (UNESP), São Paulo-
Formato: dc.format1273-1283-
Idioma: dc.languageen-
Relação: dc.relationACS Applied Bio Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectarboviruses-
Palavras-chave: dc.subjectgels-
Palavras-chave: dc.subjectnanoparticles-
Palavras-chave: dc.subjectrepellent-
Palavras-chave: dc.subjecttopical formulations-
Título: dc.titleCellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.