Antifungal activity and toxicity of an octyl gallate-loaded nanostructured lipid system on cells and nonmammalian animals

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorGuarulhos University-
Autor(es): dc.creatorSingulani, Junya L-
Autor(es): dc.creatorScorzoni, Liliana-
Autor(es): dc.creatorDa Silva, Patricia B-
Autor(es): dc.creatorNazaré, Ana C-
Autor(es): dc.creatorPolaquini, Carlos R-
Autor(es): dc.creatorBaveloni, Franciele G-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorRegasini, Luis O-
Autor(es): dc.creatorFusco-Almeida, Ana M-
Autor(es): dc.creatorMendes-Giannini, Maria J.S.-
Data de aceite: dc.date.accessioned2025-08-21T22:50:41Z-
Data de disponibilização: dc.date.available2025-08-21T22:50:41Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2217/fmb-2021-0095-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234170-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234170-
Descrição: dc.descriptionAim: Octyl gallate (OG) loaded into a nanostructured lipid system (NLS) was tested for antifungal activity and in vitro and in vivo toxicity. Methods & Results: The features of NLS-OG were analyzed by dynamic light scattering and showed adequate size (132.1 nm) and homogeneity (polydispersity index = 0.200). OG was active against Paraccoccidioides spp., and NLS-OG did not affect antifungal activity. NLS-OG demonstrated reduced toxicity to lung cells and zebrafish embryos compared with OG, whereas NLS was toxic to hepatic cells. OG and NLS-OG did not show toxicity in a Galleria mellonella model at 20 mg/kg. All toxic concentrations were superior to MIC (antifungal activity). Conclusion: These results indicate good anti-Paracoccidioides activity and low toxicity of NLS-OG.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University, Araraquara-
Descrição: dc.descriptionHumanities and Exact Sciences Institute of Biosciences São Paulo State University, São José do Rio Preto-
Descrição: dc.descriptionInstitute of Biological Sciences Federal University of Minas Gerais, Belo Horizonte-
Descrição: dc.descriptionPrograma de Pós-Graduação em Enfermagem Guarulhos University, Guarulhos-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University, Araraquara-
Descrição: dc.descriptionHumanities and Exact Sciences Institute of Biosciences São Paulo State University, São José do Rio Preto-
Formato: dc.format281-291-
Idioma: dc.languageen-
Relação: dc.relationFuture Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantifungal activity-
Palavras-chave: dc.subjectnanoparticles-
Palavras-chave: dc.subjectnonconventional animal models-
Palavras-chave: dc.subjectsystemic mycosis-
Palavras-chave: dc.subjecttoxicity-
Título: dc.titleAntifungal activity and toxicity of an octyl gallate-loaded nanostructured lipid system on cells and nonmammalian animals-
Tipo de arquivo: dc.typelivro digital-
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