Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate

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Autor(es): dc.contributorUniversity of California-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBrosnan, Robert J.-
Autor(es): dc.creatorRamos, Kimberly-
Autor(es): dc.creatorAguiar, Antonio Jose De Araujo-
Autor(es): dc.creatorCenani, Alessia-
Autor(es): dc.creatorKnych, Heather K.-
Data de aceite: dc.date.accessioned2025-08-21T22:49:54Z-
Data de disponibilização: dc.date.available2025-08-21T22:49:54Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1159/000520762-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234144-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234144-
Descrição: dc.descriptionIntroduction: Hydrocarbons with sufficient water solubility allosterically modulate anesthetic-sensitive ion channels. Mint extracts L-carvone and methyl salicylate water solubility exceeds modulation cutoff values for γ-amino butyric acid type A (GABA<sub>A</sub>) receptors, N-methyl-D-aspartate (NMDA) receptors, and type-2 voltage-gated sodium (Na<sub>v</sub>1.2) channels. We hypothesized that mint extracts modulate these channels at concentrations that anesthetize rats. Methods: Channels were expressed separately in frog oocytes and studied using 2-electrode voltage clamp techniques at drug concentrations up to 10 mM. Normalized current effects were fit to Hill equations. Mint compounds were formulated in a lipid emulsion and administered IV to rats. When unresponsive to the tail clamp, rats were exsanguinated, and plasma drug concentrations were measured. Results: Both mint compounds caused concentration-dependent inhibition of all channels except for methyl salicylate which inhibited GABA<sub>A</sub> receptors at low concentrations and potentiated at high concentrations. Plasma drug concentrations in anesthetized rats were 7.9 mM for L-carvone and 2.7 mM for methyl salicylate. This corresponded to ≥53% NMDA receptor inhibition and ≥78% Na<sub>v</sub>1.2 channel inhibition by both compounds and 30% potentiation of GABA<sub>A</sub> receptors by methyl salicylate. Conclusion: L-Carvone and methyl salicylate allosterically modulate cell receptor targets important to molecular actions of conventional anesthetics at concentrations that also induce general anesthesia in rats.-
Descrição: dc.descriptionDepartment of Surgical and Radiological Sciences School of Veterinary Medicine University of California-
Descrição: dc.descriptionDepartment of Animal Biology University of California-
Descrição: dc.descriptionDepartamento de Cirurgia Veterinária e Reprodução Animal Universidade Estadual Paulista-
Descrição: dc.descriptionCalifornia Animal Health and Food Safety Lab Department of Molecular Biosciences School of Veterinary Medicine University of California-
Descrição: dc.descriptionDepartamento de Cirurgia Veterinária e Reprodução Animal Universidade Estadual Paulista-
Idioma: dc.languageen-
Relação: dc.relationPharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnesthesia-
Palavras-chave: dc.subjectEuthanasia-
Palavras-chave: dc.subjectN-Methyl-D-aspartate-
Palavras-chave: dc.subjectVoltage-gated sodium channel-
Palavras-chave: dc.subjectγ-Amino butyric acid type-
Título: dc.titleAnesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate-
Tipo de arquivo: dc.typelivro digital-
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