Treating Inflammation Associated with Pulmonary Hypertension: An Overview of the Literature

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorState University of Western Paraná (UNIOESTE)-
Autor(es): dc.creatorYoo, Hugo Hyung Bok-
Autor(es): dc.creatorMarin, Flávia Luiza-
Data de aceite: dc.date.accessioned2025-08-21T16:39:12Z-
Data de disponibilização: dc.date.available2025-08-21T16:39:12Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2147/IJGM.S295463-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234125-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234125-
Descrição: dc.descriptionPulmonary hypertension (PH) comprises five groups of serious clinical entities characterized by pulmonary artery vasoconstriction and vascular remodeling leading to right heart failure and death. In addition to vascular remodeling, recruitment and exaggerated accumulation of several perivascular inflammatory cells is also observed, including macrophages, monocytes, T and B-lymphocytes, dendritic cells and mast cells distributed in pulmonary perivascular spaces and around remodeling pulmonary vessels. Current pulmonary arterial hypertension (PAH)-targeted therapies aim to improve functional capacity, pulmonary hemodynamic conditions, and delay disease progression. Nevertheless, PAH remains incurable, with a poor prognosis and is often refractory to drug therapy, highlighting the need for further research. In the last three decades, the best pathophysiological understanding of PAH has allowed for progression from a disease of little-known pathogenesis, without specific and effective therapy to expanding the arsenal of drugs on a cellular, genetic and molecular basis. This article provides an overview on current knowledge and progress in recent advances in pharmacological therapy in PAH.-
Descrição: dc.descriptionDepartment of Pulmonology Botucatu Medical School of São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine State University of Western Paraná (UNIOESTE), Paraná-
Descrição: dc.descriptionDepartment of Pulmonology Botucatu Medical School of São Paulo State University (UNESP), São Paulo-
Formato: dc.format1075-1083-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of General Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectPulmonary arterial hypertension-
Palavras-chave: dc.subjectTreatment-
Título: dc.titleTreating Inflammation Associated with Pulmonary Hypertension: An Overview of the Literature-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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